Malic enzyme inhibitor ME1

• 常用名: Malic enzyme inhibitor ME1
• 英文名: Malic Enzyme inhibitor ME1
• CAS号: 522649-59-8
• 分子量: 351.40
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₁N₃O₃
• 熔点: N/A
• 闪点: N/A

Malic enzyme inhibitor ME1用途

Malic enzyme inhibitor ME1 (ME1) 是一种参与糖酵解,柠檬酸循环,NADPH 产生,谷氨酰胺代谢和脂肪生成的多功能蛋白质。Malic enzyme inhibitor ME1 调节提供烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 的主要途径之一,NADPH 通过维持细胞质中的氧化还原平衡和生物合成过程对癌细胞生长至关重要。Malic enzyme inhibitor ME1 破坏癌细胞中的代谢并通过诱导衰老或凋亡来抑制癌细胞生长。

Malic enzyme inhibitor ME1名称

• 英文名: Malic enzyme inhibitor ME1

Malic enzyme inhibitor ME1生物活性

• 描述: Malic enzyme inhibitor ME1 (ME1) 是一种参与糖酵解,柠檬酸循环,NADPH 产生,谷氨酰胺代谢和脂肪生成的多功能蛋白质。Malic enzyme inhibitor ME1 调节提供烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 的主要途径之一,NADPH 通过维持细胞质中的氧化还原平衡和生物合成过程对癌细胞生长至关重要。Malic enzyme inhibitor ME1 破坏癌细胞中的代谢并通过诱导衰老或凋亡来抑制癌细胞生长。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Nakashima C, et al. Expression of cytosolic malic enzyme (ME1) is associated with disease progression in human oral squamous cell carcinoma. Cancer Sci. 2018 Jun;109(6):2036-2045.

  [2]. Murai S, et al. Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions. Oncogenesis. 2017 May 8;6(5):e329.

Malic enzyme inhibitor ME1物理化学性质

• 分子式: C₂₀H₂₁N₃O₃
• 分子量: 351.40
• InChIKey: JJFJQFJFFVLMCX-UHFFFAOYSA-N
• SMILES: O=C1CC(N2CCN(c3ccc(O)cc3)CC2)C(=O)N1c1ccccc1
• 储存条件: -20°C，密闭，干燥

Malic enzyme inhibitor ME1靶点实验

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实验名称：Antiproliferative activity against SMAD4/ME2-null human BXPC-3 cells assessed as inhi... 来源：ChEMBL 靶标：BXPC-3 External Id：CHEMBL5225650

实验名称：Selectivity for SMAD4/ME2-null human BXPC-3 cells over human HCE-T cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL5225665

实验名称：Inhibition of His-tagged human recombinant full length ME1 using L-malate and beta-NA... 来源：ChEMBL 靶标：NADP-dependent malic enzyme External Id：CHEMBL5225649

实验名称：Inhibition of recombinant His-tagged SIRT3 (unknown origin) using Fluor de Lys acetyl... 来源：ChEMBL 靶标：NAD-dependent protein deacetylase sirtuin-3, mitochondrial External Id：CHEMBL2383951

实验名称：Inhibition of His-tagged human recombinant full length ME2 using L-malate and beta-NA... 来源：ChEMBL 靶标：NAD-dependent malic enzyme, mitochondrial External Id：CHEMBL5225648

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Inhibition of His-tagged human recombinant ME3 (26 to 604 residues) using L-malate an... 来源：ChEMBL 靶标：NADP-dependent malic enzyme, mitochondrial External Id：CHEMBL5225647

实验名称：Inhibitors of CDC25B-CDK2/CyclinA interaction 来源：Center for Chemical Genomics, University of Michigan External Id：MScreen:TargetID_600

实验名称：Inhibitory activity against cytosolic malic enzyme 来源：ChEMBL 靶标：NADP-dependent malic enzyme External Id：CHEMBL859587

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