Drupanin

• 常用名: Drupanin
• 英文名: Drupanin
• CAS号: 53755-58-1
• 分子量: 232.27500
• 密度: 1.165g/cm3
• 沸点: 393.3ºC at 760 mmHg
• 分子式: C₁₄H₁₆O₃
• 熔点: N/A
• 闪点: 205.8ºC

Drupanin用途

核果苷是从绿色蜂胶中分离出来的一种化合物。核果苷可以选择性地抑制AKR1C3酶。核果苷具有研究乳腺癌的潜力[1]。

Drupanin名称

• 英文名: (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-enoic acid

Drupanin生物活性

• 描述: 核果苷是从绿色蜂胶中分离出来的一种化合物。核果苷可以选择性地抑制AKR1C3酶。核果苷具有研究乳腺癌的潜力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Rodrigues DM, et al. Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. Bioorg Med Chem. 2021;47:116372.

Drupanin物理化学性质

• 密度: 1.165g/cm3
• 沸点: 393.3ºC at 760 mmHg
• 分子式: C₁₄H₁₆O₃
• 分子量: 232.27500
• 闪点: 205.8ºC
• 精确质量: 232.11000
• PSA: 57.53000
• LogP: 2.99870
• InChIKey: HZKNHDLUFBYIQN-VMPITWQZSA-N
• SMILES: CC(C)=CCc1cc(C=CC(=O)O)ccc1O
• 折射率: 1.608

Drupanin靶点实验

查看更多实验

实验名称：Inhibition of recombinant AKR1C2 (unknown origin) assessed as reduction in S-tetralol... 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member C2 External Id：CHEMBL4430090

实验名称：Selectivity ratio of IC50 for recombinant AKR1C2 (unknown origin) to IC50 for recombi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4430091

实验名称：Antiallergic activity in Ca(2+)-stimulated differentiated human HeLa cells assessed a... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1064842

实验名称：Inhibition of AKR1C3 in human HL60 cells assessed as potentiation of etoposide-induce... 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member C3 External Id：CHEMBL4430156

实验名称：Inhibition of recombinant AKR1C3 (unknown origin) assessed as reduction in S-tetralol... 来源：ChEMBL 靶标：Aldo-keto reductase family 1 member C3 External Id：CHEMBL4430089

实验名称：Cytotoxicity against human HCT116 cells assessed as cell viability under hypoxic cond... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL1820939

实验名称：Cytotoxicity against human HCT116 cells assessed as cell viability under normoxic con... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL1820942

实验名称：Modulation of HIF1 expressed in HEK293 cells assessed as luciferase activity under hy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1820941

实验名称：Cytotoxicity against human HCT116 cells assessed as cell viability under normoxic con... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL1820944

实验名称：Cytotoxicity against human HCT116 cells assessed as cell viability under hypoxic cond... 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL1820943

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Drupanin英文别名

• (E)-3-[4-hydroxy-3-(3-methylbutenyl)phenyl]-2-propenoic acid
• (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylic acid
• 4-hydroxy-3-prenylcinnamic acid
• 3-prenyl-4-hydroxycinnamic acid
• (E)-3-(4-Hydroxy-3-(3-methyl-2-butenyl)phenyl)-2-propenoic acid
• 2-Propenoic acid,3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-,(2E)
• (E)-3-prenyl-p-coumaric acid
• drupanin