53755-58-1

• 常用中文名：Drupanin
• 常用英文名：Drupanin
• CAS号：53755-58-1
• 分子式：C₁₄H₁₆O₃
• 分子量：232.27500
• 相关类别： 研究领域 癌症
• 发布时间：2017-07-10 09:43:52
• 更新时间：2024-01-04 19:45:57
• 核果苷是从绿色蜂胶中分离出来的一种化合物。核果苷可以选择性地抑制AKR1C3酶。核果苷具有研究乳腺癌的潜力[1]。

名称

• 英文名: (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-enoic acid
• 英文别名: (E)-3-[4-hydroxy-3-(3-methylbutenyl)phenyl]-2-propenoic acid; (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylic acid; 4-hydroxy-3-prenylcinnamic acid; 3-prenyl-4-hydroxycinnamic acid; (E)-3-(4-Hydroxy-3-(3-methyl-2-butenyl)phenyl)-2-propenoic acid; 2-Propenoic acid,3-(4-hydroxy-3-(3-methyl-2-butenyl)phenyl)-,(2E); (E)-3-prenyl-p-coumaric acid; drupanin

物化性质

• 密度: 1.165g/cm3
• 沸点: 393.3ºC at 760 mmHg
• 分子式: C₁₄H₁₆O₃
• 分子量: 232.27500
• 闪点: 205.8ºC
• 精确质量: 232.11000
• PSA: 57.53000
• LogP: 2.99870
• 折射率: 1.608

生物活性

• 描述: 核果苷是从绿色蜂胶中分离出来的一种化合物。核果苷可以选择性地抑制AKR1C3酶。核果苷具有研究乳腺癌的潜力[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Rodrigues DM, et al. Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. Bioorg Med Chem. 2021;47:116372.

合成路线

72704-01-9 ~87% 53755-58-1

文献：Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M. Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106

1208233-14-0 ~60% 53755-58-1

文献：Tani, Hiroko; Hasumi, Keiko; Tatefuji, Tomoki; Hashimoto, Ken; Koshino, Hiroyuki; Takahashi, Shunya Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 151 - 157

151071-02-2 ~82% 53755-58-1

文献：Bates, Roderick W.; Gabel, Christine J.; Ji, Jianhua; Rama-Devi, Thota Tetrahedron, 1995 , vol. 51, # 30 p. 8199 - 8212

540-38-5 ~% 53755-58-1

文献：Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728

151071-03-3 ~% 53755-58-1

文献：Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728

151071-04-4 ~% 53755-58-1

文献：Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728

870-63-3 ~% 53755-58-1

文献：Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728

7400-08-0 ~% 53755-58-1

文献：Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M. Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106

3943-97-3 ~% 53755-58-1

文献：Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M. Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106

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