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6-氯嘌呤核苷

更新时间:2024-01-02 15:02:20

6-氯嘌呤核苷结构式
6-氯嘌呤核苷结构式
品牌特惠专场
常用名 6-氯嘌呤核苷 英文名 6-Chloropurineriboside
CAS号 5399-87-1 分子量 286.67
密度 2.0±0.1 g/cm3 沸点 614.8±65.0 °C at 760 mmHg
分子式 C10H11ClN4O4 熔点 161-163ºC (dec.)
MSDS 美版 闪点 325.6±34.3 °C

 6-氯嘌呤核苷用途


氯嘌呤核苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

 6-氯嘌呤核苷名称

中文名 6-氯嘌呤核苷
英文名 6-Chloropurine riboside
中文别名 6-氯嘌呤苷 | 6-氯嘌呤-9-β-D-呋喃核糖苷
英文别名 更多

 6-氯嘌呤核苷生物活性

描述 氯嘌呤核苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
相关类别
参考文献

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 6-氯嘌呤核苷物理化学性质

密度 2.0±0.1 g/cm3
沸点 614.8±65.0 °C at 760 mmHg
熔点 161-163ºC (dec.)
分子式 C10H11ClN4O4
分子量 286.67
闪点 325.6±34.3 °C
精确质量 286.046875
PSA 113.52000
LogP -0.56
外观性状 无色结晶粉末
蒸汽压 0.0±1.9 mmHg at 25°C
折射率 1.846
储存条件 2-8°C

 6-氯嘌呤核苷MSDS

 6-氯嘌呤核苷安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危害码 (欧洲) Xi
安全声明 (欧洲) S24/25
危险品运输编码 NONH for all modes of transport
海关编码 2942000000

 6-氯嘌呤核苷海关

海关编码 2934999090
中文概述 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 6-氯嘌呤核苷文献15

更多文献
Evidence on the existence of a purine ligand induced conformational change in the active site of bovine pancreatic ribonuclease A studied by proton nuclear magnetic resonance spectroscopy.

Biochemistry 21(18) , 4290-7, (1982)

The titration curves of the C-2 histidine protons of RNase A and of derivative II--a covalent derivative obtained by reaction of the enzyme with the halogenated nucleotide 9-beta-D-ribofuranosyl-6-chl...

Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.

Biochem. Pharmacol. 73 , 1558-1572, (2007)

Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and depends on salvage pathways for its purine re...

Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents.

Bioorg. Med. Chem. Lett. 17 , 2470-3, (2007)

Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-...

 6-氯嘌呤核苷英文别名

6-Chloronebularine
6-CHLOROINOSINE
9H-Purine, 6-chloro-9-β-D-ribofuranosyl-
6-Chloropurine riboside
6-Chloropurine ribos
(2R,3R,4S,5R)-2-(6-Chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydro-3,4-furandiol
6-Choropurine Riboside
6-Chloropurineriboside
6-Chloropurine-9-Beta-D-ribofuranoside
EINECS 217-904-8
(2R,3R,4S,5R)-2-(6-Chloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
2',3',5'-tri-O-acetyl-6-chloro adenosine
6-Chlorpurinribosid
9H-purine, 6-chloro-9-(β-d-ribofuranosyl)-
6-CLPR
6-Chloro-9-(β-D-ribofuranosyl)-9H-purine
6-Chloro-9-(β-D-ribofuranosyl)purine
MFCD00005738
6-Chloro-6-deoxyinosine
6-CHLOROPURINE NUCLEOSIDE
6-Chlrorpurine riboside
6-Cl-riboside
6-deamino-6-chloroadenosine
6-Chloro-9-b-D-ribofuranosyl-9H-purine
6-Chloropurine-9-β-D-ribofuranoside
6-chloro-9-pentofuranosylpurine
6-Chloropurinosine
6-Chloropurine ribose
6-Chlor-9-ss-D-ribofuranosylpurin
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