Vacquinol-1

• 常用名: Vacquinol-1
• 英文名: Vacquinol-1
• CAS号: 5428-80-8
• 分子量: 352.857
• 密度: 1.2±0.1 g/cm3
• 沸点: 551.4±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₁ClN₂O
• 熔点: N/A
• 闪点: 287.3±30.1 °C

Vacquinol-1用途

Vacquinol-1(NSC13316)是一种MKK4特异性激活剂,可激活MAPK途径[1]。在多形性胶质母细胞瘤(GBM)小鼠模型中,Vacquinol-1特异性诱导人胶质母细胞瘤细胞(GC)死亡,减轻肿瘤进展,延长生存期[2]。Vacquinol-1还诱导肝细胞癌(HCC)细胞凋亡[3]。

Vacquinol-1名称

• 中文名: Vacquinol-1
• 英文名: [2-(4-chlorophenyl)quinolin-4-yl]-piperidin-2-ylmethanol

Vacquinol-1生物活性

• 描述: Vacquinol-1(NSC13316)是一种MKK4特异性激活剂,可激活MAPK途径[1]。在多形性胶质母细胞瘤(GBM)小鼠模型中,Vacquinol-1特异性诱导人胶质母细胞瘤细胞(GC)死亡,减轻肿瘤进展,延长生存期[2]。Vacquinol-1还诱导肝细胞癌(HCC)细胞凋亡[3]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563.

  [2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137.

  [3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881.

  [4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1.

  [5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

Vacquinol-1物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 551.4±50.0 °C at 760 mmHg
• 分子式: C₂₁H₂₁ClN₂O
• 分子量: 352.857
• 闪点: 287.3±30.1 °C
• 精确质量: 352.134247
• PSA: 45.15000
• LogP: 3.87
• InChIKey: VKLJPGAHSLIQKH-UHFFFAOYSA-N
• SMILES: OC(c1cc(-c2ccc(Cl)cc2)nc2ccccc12)C1CCCCN1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.643
• 储存条件: -20℃

Vacquinol-1安全信息

• 海关编码: 2933990090

Vacquinol-1海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Vacquinol-1靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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Vacquinol-1英文别名

• (2-(4-chlorophenyl)-4-quinolinyl)(2-piperidinyl)methanol
• [2-(4-chlorophenyl)quinolin-4-yl](piperidin-2-yl)methanol
• [2-(4-chloro-phenyl)-[4]quinolyl]-[2]piperidyl-methanol
• [2-(4-Chlor-phenyl)-[4]chinolyl]-[2]piperidyl-methanol
• [2-(4-Chlorophenyl)-4-quinolinyl](2-piperidinyl)methanol
• Vacquinol-1