NHE3-IN-3

• 常用名: NHE3-IN-3
• 英文名: NHE3-IN-3
• CAS号: 543734-50-5
• 分子量: 371.28
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₆Cl₂N₂O₂S
• 熔点: N/A
• 闪点: N/A

NHE3-IN-3用途

NHE3-IN-3(化合物1)是一种Na+/H+交换异构体3(NHE3)抑制剂,其pIC50分别为6.2和6.6,可对抗人和大鼠NHE3。NHE3-IN-3在Sprague–Dawley大鼠中的口服生物利用度高(98%)[1]。

NHE3-IN-3名称

• 英文名: NHE3-IN-3

NHE3-IN-3生物活性

• 描述: NHE3-IN-3(化合物1)是一种Na+/H+交换异构体3(NHE3)抑制剂,其pIC50分别为6.2和6.6,可对抗人和大鼠NHE3。NHE3-IN-3在Sprague–Dawley大鼠中的口服生物利用度高(98%)[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 代谢疾病
• 靶点实验:

  pIC50: 6.6 (rat NHE3), 6.2 (human NHE3)[1]

• 参考文献:

  [1]. Jacobs JW, et al. Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3. ACS Med Chem Lett. 2022 Apr 11;13(7):1043-1051.

NHE3-IN-3物理化学性质

• 分子式: C₁₆H₁₆Cl₂N₂O₂S
• 分子量: 371.28

NHE3-IN-3靶点实验

查看更多实验

实验名称：In vivo inhibition of NHE3 in Sprague-Dawley rat assessed as inhibition of sodium abs... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4257111

实验名称：Inhibition of rat NHE3-mediated sodium-dependant hydrogen ion antiport in Opossum kid... 来源：ChEMBL 靶标：Sodium/hydrogen exchanger 3 External Id：CHEMBL3881393

实验名称：Apparent permeability in MDCK cells at 10 uM measured after 60 mins by LC-MS/MS analy... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149747

实验名称：Effect on sodium level in urine in Sprague-Dawley rat at 10 mg/kg administered via or... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3881395

实验名称：Inhibition of human NHE3 expressed in opossum kidney cells assessed as reduction in N... 来源：ChEMBL 靶标：Sodium/hydrogen exchanger 3 External Id：CHEMBL5149726

实验名称：Inhibition of rat NHE3 expressed in opossum kidney cells assessed as reduction in Na-... 来源：ChEMBL 靶标：Sodium/hydrogen exchanger 3 External Id：CHEMBL5149727

实验名称：Inhibition of rat NHE3 expressed in OK cells assessed as reduction in Na+ dependent H... 来源：ChEMBL 靶标：Sodium/hydrogen exchanger 3 External Id：CHEMBL4257109

实验名称：Dose normalized AUC in Sprague-Dawley rat at 11 mg/kg, po administered via gavage by ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149729

实验名称：Cell-based activity under Prompt Conditions from US Patent US10272079: "NHE3-binding ... 来源：BindingDB 靶标：N/A External Id：BindingDB_2819_1

实验名称：Oral bioavailability in Sprague-Dawley rat at 11 mg/kg administered via gavage by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5149734

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