U-0521

• 常用名: U-0521
• 英文名: U-0521
• CAS号: 5466-89-7
• 分子量: 180.20000
• 密度: 1.191g/cm3
• 沸点: 372.2ºC at 760mmHg
• 分子式: C₁₀H₁₂O₃
• 熔点: N/A
• 闪点: 193.1ºC

U-0521用途

U-0521是儿茶酚-O-甲基转移酶(COMT)的抑制剂。U-0521具有研究帕金森病的潜力[1]。

U-0521名称

• 中文名: 3',4'-Dihydroxy-2-methylpropiophenone
• 英文名: 1-(3,4-dihydroxyphenyl)-2-methylpropan-1-one

U-0521生物活性

• 描述: U-0521是儿茶酚-O-甲基转移酶(COMT)的抑制剂。U-0521具有研究帕金森病的潜力[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 靶点实验:

  COMT[1]

• 体外研究: U-0521以剂量依赖性方式抑制红细胞COMT活性,IC50为6 x10-6 M[1]。
• 体内研究: U-0521(腹腔注射；0-250 mg/kg；10分钟)以剂量依赖性方式抑制COMT活性。90 mg/kg时酶活性抑制率为50%,250 mg/kg时酶活性抑制率最高为90%[1]。动物模型：雄性Sprague-Dawley大鼠(180-250 g)[1]剂量：0-250 mg/kg给药：腹腔注射。；10分钟结果：以剂量依赖性方式抑制COMT活性。90mg/kg时酶活性抑制率为50%,250mg/kg时酶活性最大抑制率为90%。
• 参考文献:

  [1]. Reches A, et al. Effect of 3',4'-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. Biochem Pharmacol. 1982;31(21):3415-3418.

U-0521物理化学性质

• 密度: 1.191g/cm3
• 沸点: 372.2ºC at 760mmHg
• 分子式: C₁₀H₁₂O₃
• 分子量: 180.20000
• 闪点: 193.1ºC
• 精确质量: 180.07900
• PSA: 57.53000
• LogP: 1.93650
• InChIKey: VDQLKIBLTMPAHI-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)c1ccc(O)c(O)c1
• 外观性状: 固体
• 折射率: 1.565
• 储存条件: 2-8°C，密封，干燥

U-0521毒性和生态

U-0521安全信息

• 海关编码: 2914501900

U-0521海关

• 海关编码: 2914501900
• 中文概述: 2914501900 其他酮酚。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

U-0521靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：In vitro inhibitory activity against catechol O-methyltransferase of rat brain using ... 来源：ChEMBL 靶标：Catechol O-methyltransferase External Id：CHEMBL661106

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

共126条，当前第1页，共13页

1

2

3

4

5

U-0521英文别名

• U-0521
• 3',4'-Dihydroxyisobutyrophenone
• 3,4-Dihydroxyisobutyrophenon
• 3,4-Dihydroxyphenyl-isopropylketon
• 3',4'-Dihydroxy-2-methylpropiophenone