U-0521
Modify Date: 2025-08-26 21:21:30
U-0521 structure
|
Common Name | U-0521 | ||
|---|---|---|---|---|
| CAS Number | 5466-89-7 | Molecular Weight | 180.20000 | |
| Density | 1.191g/cm3 | Boiling Point | 372.2ºC at 760mmHg | |
| Molecular Formula | C10H12O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 193.1ºC | |
Use of U-0521U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson's disease[1]. |
| Name | 1-(3,4-dihydroxyphenyl)-2-methylpropan-1-one |
|---|---|
| Synonym | More Synonyms |
| Description | U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson's disease[1]. |
|---|---|
| Related Catalog | |
| Target |
COMT[1] |
| In Vitro | U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC50 of 6 x10-6 M[1]. |
| In Vivo | U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg[1]. Animal Model: Male Sprague-Dawley rats (180-250 g)[1] Dosage: 0-250 mg/kg Administration: i.p.; 10 min Result: Inhibited COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity was obtained at 90mg/kg and maximum inhibition of 90% was obtained at 250 mg/kg. |
| References |
| Density | 1.191g/cm3 |
|---|---|
| Boiling Point | 372.2ºC at 760mmHg |
| Molecular Formula | C10H12O3 |
| Molecular Weight | 180.20000 |
| Flash Point | 193.1ºC |
| Exact Mass | 180.07900 |
| PSA | 57.53000 |
| LogP | 1.93650 |
| Index of Refraction | 1.565 |
| InChIKey | VDQLKIBLTMPAHI-UHFFFAOYSA-N |
| SMILES | CC(C)C(=O)c1ccc(O)c(O)c1 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| HS Code | 2914501900 |
|---|
| Precursor 0 | |
|---|---|
| DownStream 1 | |
CAS#:67464-98-6| HS Code | 2914501900 |
|---|---|
| Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
| U-0521 |
| 3',4'-Dihydroxyisobutyrophenone |
| 3,4-Dihydroxyisobutyrophenon |
| 3,4-Dihydroxyphenyl-isopropylketon |
| 3',4'-Dihydroxy-2-methylpropiophenone |