U-0521 structure
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Common Name | U-0521 | ||
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CAS Number | 5466-89-7 | Molecular Weight | 180.20000 | |
Density | 1.191g/cm3 | Boiling Point | 372.2ºC at 760mmHg | |
Molecular Formula | C10H12O3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 193.1ºC |
Use of U-0521U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson's disease[1]. |
Name | 1-(3,4-dihydroxyphenyl)-2-methylpropan-1-one |
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Synonym | More Synonyms |
Description | U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT). U-0521 has the potential for the research of Parkinson's disease[1]. |
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Related Catalog | |
Target |
COMT[1] |
In Vitro | U-0521 inhibits RBC COMT activity in a dose-dependent manner with an IC50 of 6 x10-6 M[1]. |
In Vivo | U-0521 (i.p.; 0-250 mg/kg; 10 min) inhibits COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity is obtained at 90 mg/kg and maximum inhibition of 90% is obtained at 250 mg/kg[1]. Animal Model: Male Sprague-Dawley rats (180-250 g)[1] Dosage: 0-250 mg/kg Administration: i.p.; 10 min Result: Inhibited COMT activity in a dose-dependent manner. 50% inhibition of enzyme activity was obtained at 90mg/kg and maximum inhibition of 90% was obtained at 250 mg/kg. |
References |
Density | 1.191g/cm3 |
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Boiling Point | 372.2ºC at 760mmHg |
Molecular Formula | C10H12O3 |
Molecular Weight | 180.20000 |
Flash Point | 193.1ºC |
Exact Mass | 180.07900 |
PSA | 57.53000 |
LogP | 1.93650 |
Index of Refraction | 1.565 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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HS Code | 2914501900 |
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Precursor 0 | |
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DownStream 1 | |
HS Code | 2914501900 |
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Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
U-0521 |
3',4'-Dihydroxyisobutyrophenone |
3,4-Dihydroxyisobutyrophenon |
3,4-Dihydroxyphenyl-isopropylketon |
3',4'-Dihydroxy-2-methylpropiophenone |