Necroptosis-IN-3

• 常用名: Necroptosis-IN-3
• 英文名: Necroptosis-IN-3
• CAS号: 547698-18-0
• 分子量: 223.34
• 密度: 1.1±0.1 g/cm3
• 沸点: 422.4±24.0 °C at 760 mmHg
• 分子式: C₁₂H₁₇NOS
• 熔点: N/A
• 闪点: 209.3±22.9 °C

Necroptosis-IN-3用途

坏死素-3(化合物69)是一种抑制TNF-α诱导的坏死的坏死抑制剂[1]。坏死因子-IN-3(化合物STX1638)也抑制11β-HSD1[2]。

Necroptosis-IN-3名称

• 英文名: WAY-620847

Necroptosis-IN-3生物活性

• 描述: 坏死素-3(化合物69)是一种抑制TNF-α诱导的坏死的坏死抑制剂[1]。坏死因子-IN-3(化合物STX1638)也抑制11β-HSD1[2]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 炎症/免疫
• 靶点实验:

  Necroptosis[1], 11β-HSD1[2]

• 体外研究: TNF-α-IN-8(化合物69)(0.030-100μM；24小时)抑制 肿瘤坏死因子-α诱导的 1.FADD的过去分词缺陷人 Jurkat T公司细胞坏死[1]。 细胞活力测定[1]细胞系：Fadd-/-Jurkat和L929细胞,用10 ng/mL人TNF-α浓度：0.030-100μM培养时间：24小时结果：Fadd/-Jurkat细胞表现出坏死抑制活性,ED50为7.724μM,对L929细胞无活性。
• 参考文献:

  [1]. Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1.

  [2]. Nigel Vicker, et al. Compound. Patent US20100120789A1.

Necroptosis-IN-3物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 422.4±24.0 °C at 760 mmHg
• 分子式: C₁₂H₁₇NOS
• 分子量: 223.34
• 闪点: 209.3±22.9 °C
• 精确质量: 223.103088
• LogP: 2.48
• InChIKey: QTYJPNRSYXQPSF-UHFFFAOYSA-N
• SMILES: O=C(NCc1cccs1)C1CCCCC1
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.557
• 储存条件: -80℃储存

Necroptosis-IN-3靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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Necroptosis-IN-3英文别名

• N-(2-Thienylmethyl)cyclohexanecarboxamide
• MFCD03397171