ML 3403

• 常用名: ML 3403
• 英文名: ML 3403
• CAS号: 549505-65-9
• 分子量: 404.50300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₁FN₄S
• 熔点: N/A
• 闪点: N/A

ML 3403用途

ML3403是一种有效的p38 MAPK抑制剂,IC50为0.38μM【1】。

ML 3403名称

• 英文名: 4-[4-(4-Fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]-N-(1-p henylethyl)-2-pyridinamine

ML 3403生物活性

• 描述: ML3403是一种有效的p38 MAPK抑制剂,IC50为0.38μM【1】。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Kammerer B, et al. Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab Dispos. 2007 Jun;35(6):875-83.

ML 3403物理化学性质

• 分子式: C₂₃H₂₁FN₄S
• 分子量: 404.50300
• 精确质量: 404.14700
• PSA: 78.90000
• LogP: 6.24580
• InChIKey: VXPWQNBKEIVYIS-UHFFFAOYSA-N
• SMILES: CSc1nc(-c2ccnc(NC(C)c3ccccc3)c2)c(-c2ccc(F)cc2)[nH]1

ML 3403靶点实验

查看更多实验

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

实验名称：Delta TM value showing the stabilisation of CAMK2B produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta External Id：CHEMBL3430793

实验名称：Delta TM value showing the stabilisation of CAMK2D produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta External Id：CHEMBL3430794

实验名称：Delta TM value showing the stabilisation of CDK6 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 6 External Id：CHEMBL3430799

实验名称：Delta TM value showing the stabilisation of CDKL1 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1 External Id：CHEMBL3430800

实验名称：Delta TM value showing the stabilisation of CAMKK2 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2 External Id：CHEMBL3430797

实验名称：Delta TM value showing the stabilisation of CDK2 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL3430798

实验名称：Delta TM value showing the stabilisation of CLK2 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL3430803

实验名称：Delta TM value showing the stabilisation of CLK3 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK3 External Id：CHEMBL3430804

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ML 3403英文别名

• p38 MAP inhibitor III