氟喹酮

• 常用名: 氟喹酮
• 英文名: Afloqualone
• CAS号: 56287-74-2
• 分子量: 283.300
• 密度: 1.3±0.1 g/cm3
• 沸点: 492.5±55.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄FN₃O
• 熔点: 195-196ºC
• 闪点: 251.7±31.5 °C

氟喹酮用途

Afloqualone是一种GABA_A受体β亚型激动剂。

氟喹酮名称

• 中文名: 氟喹酮
• 英文名: 6-amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one

氟喹酮生物活性

• 描述: Afloqualone是一种GABA_A受体β亚型激动剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> GABA受体
  信号通路 >> 神经信号通路 >> GABA受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Yamamura M, et al. Effects of afloqualone, a new centrally acting muscle relaxant, on DRL response and CER in rats (author's transl). Nihon Yakurigaku Zasshi. 1981 Oct;78(4):381-92.

氟喹酮物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 492.5±55.0 °C at 760 mmHg
• 熔点: 195-196ºC
• 分子式: C₁₆H₁₄FN₃O
• 分子量: 283.300
• 闪点: 251.7±31.5 °C
• 精确质量: 283.112091
• PSA: 60.91000
• LogP: 1.28
• InChIKey: VDOSWXIDETXFET-UHFFFAOYSA-N
• SMILES: Cc1ccccc1-n1c(CF)nc2ccc(N)cc2c1=O
• 外观性状: 白色至浅黄色结晶或结晶性粉末
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.642
• 储存条件: 库房通风低温干燥,与食品原料分开存放

氟喹酮MSDS

氟喹酮MSDS英文版

氟喹酮毒性和生态

氟喹酮靶点实验

查看更多实验

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291791

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

实验名称：Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5291777

实验名称：Binding affinity towards human CNR1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291773

实验名称：Binding affinity towards human MC4R in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Melanocortin receptor 4 External Id：CHEMBL5291832

实验名称：qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr... 来源：824 靶标：N/A External Id：SPEC167MG

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氟喹酮英文别名

• Arofuto
• Aroft
• Afloqualonum [INN-Latin]
• Afloqualone
• 6-amino-2-fluoromethyl-3-o-tolyl-3H-quinazolin-4-one
• 6-amino-2-fluoromethyl-3-(o-tolyl)-4(3H)-quinazolinone
• 2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone
• 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)-4(3H)-quinazolinone
• 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4(3H)-one
• MFCD00867693
• Afloqualona [INN-Spanish]
• HQ 495
• Afloqualon
• Afloqualone [INN:JAN]