N-acetyl Dapsone

• 常用名: N-acetyl Dapsone
• 英文名: N-acetyl Dapsone
• CAS号: 565-20-8
• 分子量: 290.34
• 密度: 1.362g/cm3
• 沸点: 589.5ºC at 760mmHg
• 分子式: C₁₄H₁₄N₂O₃S
• 熔点: 238-240ºC
• 闪点: 310.3ºC

N-acetyl Dapsone用途

N-Acetyl dapsone (MADDS) 是 Dapsone (HY-B0688) 的主要代谢物。Dapsone 是一种具有口服活性的血脑渗透磺胺类抗生素,具有抑细菌、抑分支杆菌和抗原虫活性。

N-acetyl Dapsone名称

• 中文名: N-乙酰氨苯砜
• 英文名: N-Acetyl Dapsone

N-acetyl Dapsone生物活性

• 描述: N-Acetyl dapsone (MADDS) 是 Dapsone (HY-B0688) 的主要代谢物。Dapsone 是一种具有口服活性的血脑渗透磺胺类抗生素,具有抑细菌、抑分支杆菌和抗原虫活性。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5.

  [2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

N-acetyl Dapsone物理化学性质

• 密度: 1.362g/cm3
• 沸点: 589.5ºC at 760mmHg
• 熔点: 238-240ºC
• 分子式: C₁₄H₁₄N₂O₃S
• 分子量: 290.34
• 闪点: 310.3ºC
• 精确质量: 290.07300
• PSA: 97.64000
• LogP: 3.79500
• InChIKey: WDOCBIHNYYQINH-UHFFFAOYSA-N
• SMILES: CC(=O)Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1
• 外观性状: 白色
• 折射率: 1.641
• 储存条件: 2-8°C

N-acetyl Dapsone毒性和生态

N-acetyl Dapsone安全信息

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): 37/38-41-43
• 安全声明 (欧洲): 26-36/37/39
• WGK德国: 2
• RTECS号: AE7020000

N-acetyl Dapsone靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation... 来源：NMMLSC 靶标：ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] External Id：UNMCMD_ABCB6_1o_ValidationSet

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

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N-acetyl Dapsone英文别名

• N-[4-(4-aminophenyl)sulfonylphenyl]acetamide
• Mono-N-acetyl-4-4'-sulfonylbisbenzeneamine