N-acetyl Dapsone

Modify Date: 2026-08-02 11:04:58

N-acetyl Dapsone structure	Common Name	N-acetyl Dapsone
	CAS Number	565-20-8	Molecular Weight	290.34
	Density	1.362g/cm3	Boiling Point	589.5ºC at 760mmHg
	Molecular Formula	C₁₄H₁₄N₂O₃S	Melting Point	238-240ºC
	MSDS	N/A	Flash Point	310.3ºC

Use of N-acetyl Dapsone

N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].

Name	N-Acetyl Dapsone
Synonym	More Synonyms

Description	N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5. [2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5.

[2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

Density	1.362g/cm3
Boiling Point	589.5ºC at 760mmHg
Melting Point	238-240ºC
Molecular Formula	C₁₄H₁₄N₂O₃S
Molecular Weight	290.34
Flash Point	310.3ºC
Exact Mass	290.07300
PSA	97.64000
LogP	3.79500
Index of Refraction	1.641
InChIKey	WDOCBIHNYYQINH-UHFFFAOYSA-N
SMILES	CC(=O)Nc1ccc(S(=O)(=O)c2ccc(N)cc2)cc1
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AE7020000

CHEMICAL NAME :: Acetanilide, 4'-sulfanilyl-

CAS REGISTRY NUMBER :: 565-20-8

BEILSTEIN REFERENCE NO. :: 2746651

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H14-N2-O3-S

MOLECULAR WEIGHT :: 290.36

WISWESSER LINE NOTATION :: ZR DSWR DMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 6,251,1951

Hazard Codes	Xi
Risk Phrases	37/38-41-43
Safety Phrases	26-36/37/39
WGK Germany	2
RTECS	AE7020000

Precursor 10
CAS#:1775-37-7 Acetamide,N-[4-... CAS#:7467-51-8 Acetamide,N-[4-... CAS#:586-78-7 1-Bromo-4-nitro... CAS#:101-59-7 p-[(p-Nitrophen...
CAS#:710-24-7 BENZENESULFINIC... CAS#:108-24-7 Ethanoic anhydride CAS#:80-08-0 4,4'-Diaminodip... CAS#:100-00-5 4-Chloronitrobenzene
CAS#:1948-92-1 Benzenamine,4-[... CAS#:122-80-5 4'-Aminoacetanilide
DownStream 7
CAS#:80-08-0 4,4'-Diaminodip... CAS#:3572-34-7 Benzenamine,4-[... CAS#:6973-61-1 Acetamide,N-[4-... CAS#:7248-33-1 Butanamide,N-[4...
CAS#:77-46-3 acedapsone CAS#:6345-91-1 N-[4-(4-acetami... CAS#:51688-26-7 4-[4-(methylami...

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

Name: High throughput fluorescence intensity-based biochemical assay to screen for small mo...
Source: University of Pittsburgh Molecular Library Screening Center
Target: furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens]
External Id: MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity

Name: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect...
Source: Broad Institute
Target: N/A
External Id: Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

Name: Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation...
Source: NMMLSC
Target: ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens]
External Id: UNMCMD_ABCB6_1o_ValidationSet

Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity

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N-[4-(4-aminophenyl)sulfonylphenyl]acetamide

Mono-N-acetyl-4-4'-sulfonylbisbenzeneamine

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N-acetyl Dapsone

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.