噻帕米盐酸盐

• 常用名: 噻帕米盐酸盐
• 英文名: Tiapamil hydrochloride
• CAS号: 57010-32-9
• 分子量: 592.165
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₈ClNO₈S₂
• 熔点: N/A
• 闪点: N/A

噻帕米盐酸盐用途

Tiapamil hydrochloride 是一种钙离子 (Calcium channel) 阻断剂。

噻帕米盐酸盐名称

• 中文名: 盐酸泰妙帕米
• 英文名: Tiapamil hydrochloride

噻帕米盐酸盐生物活性

• 描述: Tiapamil hydrochloride 是一种钙离子 (Calcium channel) 阻断剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 靶点实验:

  Calcium channel[1]

• 体外研究: Tiapamil,一种新的钙拮抗剂：急性心肌梗死患者的血流动力学效应。 Tiapamil是一种新的维拉帕米同系物。没有引起左心室衰竭,Tiapamil减少了后负荷和心率,维持了心脏指数,同时明显改善了舒张顺应性[1]。 Tiapamil,一种具有抗心绞痛作用的新型钙通道阻滞剂[2]。
• 参考文献:

  [1]. Eichler HG, et al. Tiapamil, a new calcium antagonist: hemodynamic effects in patients with acute myocardial infarction. Circulation. 1985 Apr;71(4):779-86.

  [2]. Khurmi NS, et al. Tiapamil, a new calcium channel blocking agent for the treatment of effort induced chronic stableangina pectoris.

噻帕米盐酸盐物理化学性质

• 分子式: C₂₆H₃₈ClNO₈S₂
• 分子量: 592.165
• 精确质量: 591.172729
• InChIKey: FEEDFNKRGAKOFI-UHFFFAOYSA-N
• SMILES: COc1ccc(CCN(C)CCCC2(c3ccc(OC)c(OC)c3)S(=O)(=O)CCCS2(=O)=O)cc1OC.Cl
• 储存条件: -20°C，密闭，干燥

噻帕米盐酸盐靶点实验

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实验名称：Oral bioavailability in human 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL926687

实验名称：Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum act... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137722

实验名称：Highest frequency of moderate liver toxicity observed during clinical trials, express... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137723

实验名称：Acute liver toxicity defined via clinical observations and clear clinical-chemistry r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137724

实验名称：Highest frequency of acute liver toxicity observed during clinical trials, expressed ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137725

实验名称：Cytolytic liver toxicity, either proven histopathologically or where the ratio of max... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137726

实验名称：Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage ... 来源：ChEMBL 靶标：Sodium channel protein type 3 subunit alpha External Id：CHEMBL806152

实验名称：Choleostatic liver toxicity, either proven histopathologically or where the ratio of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137727

实验名称：Severe hepatitis, defined as possibly life-threatening liver failure or through clini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137728

实验名称：Chronic liver disease either proven histopathologically, or through a chonic elevatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137729

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噻帕米盐酸盐英文别名

• N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-[2-(3,4-dimethoxyphenyl)-1,1,3,3-tetraoxido-1,3-dithian-2-yl]-N-methyl-1-propanaminium chloride
• 2-(3,4-Dimethoxyphenyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-N-methyl-1,3-dithiane-2-propanamine 1,1,3,3-tetraoxide hydrochloride
• dimeditiapramine
• N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-[2-(3,4-dimethoxyphenyl)-1,1,3,3-tetraoxido-1,3-dithian-2-yl]-N-methylpropan-1-amine hydrochloride (1:1)
• S3R8JZ9DJH
• TIAPAMIL HYDROCHLORIDE ANHYDROUS
• 1,3-Dithiane-2-propanaminium, 2-(3,4-dimethoxyphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methyl-, chloride, 1,1,3,3-tetraoxide (1:1)
• EINECS 260-511-1