马来酸阿伐曲波帕

• 常用名: 马来酸阿伐曲波帕
• 英文名: avatrombopag
• CAS号: 570406-98-3
• 分子量: 649.655
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₉H₃₄Cl₂N₆O₃S₂
• 熔点: N/A
• 闪点: N/A

马来酸阿伐曲波帕用途

Avatrombopag(AKR-501;AS1670542)是血小板生成素受体(TPO受体)的新型具口服活性激动剂,EC50值为3.3nM。

马来酸阿伐曲波帕名称

• 中文名: 1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4-环己基-1-哌嗪基)-2-噻唑基]氨基]羰基]-2-吡啶基]-4-哌啶羧酸
• 英文名: 1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
• 中文别名: 马来酸阿伐曲波帕

马来酸阿伐曲波帕生物活性

• 描述: Avatrombopag(AKR-501;AS1670542)是血小板生成素受体(TPO受体)的新型具口服活性激动剂,EC50值为3.3nM。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 血小板生成素受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Fukushima-Shintani M, et al. AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol. 2009 Apr;82(4):247-54.

  [2]. Abe M, et al. Pharmacological profile of AS1670542, a novel orally-active human thrombopoietin receptor agonist. Eur J Pharmacol. 2011 Jan 10;650(1):58-63.

马来酸阿伐曲波帕物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₉H₃₄Cl₂N₆O₃S₂
• 分子量: 649.655
• 精确质量: 648.151062
• PSA: 161.87000
• LogP: 6.82
• InChIKey: OFZJKCQENFPZBH-UHFFFAOYSA-N
• SMILES: O=C(Nc1nc(-c2cc(Cl)cs2)c(N2CCN(C3CCCCC3)CC2)s1)c1cnc(N2CCC(C(=O)O)CC2)c(Cl)c1
• 折射率: 1.671
• 储存条件: 2-8℃

马来酸阿伐曲波帕靶点实验

查看更多实验

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291800

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：Binding affinity towards human GABBR1 in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Gamma-aminobutyric acid type B receptor subunit 1 External Id：CHEMBL5291795

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Compound was evaluated for inhibition of human F2 in an in vitro cell free assay meas... 来源：ChEMBL 靶标：Prothrombin External Id：CHEMBL5291794

实验名称：Binding affinity towards human DRD5 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(1B) dopamine receptor External Id：CHEMBL5291784

实验名称：Binding affinity towards human DRD4 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(4) dopamine receptor External Id：CHEMBL5291783

实验名称：Binding affinity towards human EDNRB in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Endothelin receptor type B External Id：CHEMBL5291786

实验名称：Binding affinity towards human EDNRA in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Endothelin-1 receptor External Id：CHEMBL5291785

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马来酸阿伐曲波帕英文别名

• avatrombopag
• 1-(3-Chloro-5-{[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-1,3-thiazol-2-yl]carbamoyl}-2-pyridinyl)-4-piperidinecarboxylic acid
• E-5501
• 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid
• ym477
• unii-3h8gsz4sql
• e5501
• akr-501