帕米膦酸二钠

• 常用名: 帕米膦酸二钠
• 英文名: Pamidronate disodium
• CAS号: 57248-88-1
• 分子量: 281.05
• 密度: N/A
• 沸点: N/A
• 分子式: C₃H₁₁NNa₂O₇P₂
• 熔点: 300 °C
• 闪点: N/A

帕米膦酸二钠用途

Pamidronate二钠盐可强化骨骼。

帕米膦酸二钠名称

• 中文名: 帕米膦酸钠
• 英文名: Disodium Pamidronate Hydrate
• 中文别名: 帕米瞵酸二钠盐 | 3-氨基-1-羟基丙亚基-1,1-二磷酸二钠 | 帕米膦酸二钠

帕米膦酸二钠生物活性

• 描述: Pamidronate二钠盐可强化骨骼。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Zarychanski, R., et al., Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol, 2006. 81(1): p. 73-5.

帕米膦酸二钠物理化学性质

• 熔点: 300 °C
• 分子式: C₃H₁₁NNa₂O₇P₂
• 分子量: 281.05
• PSA: 186.59000
• InChIKey: MXOIKYVGQDEWSQ-UHFFFAOYSA-N
• SMILES: NCCC(O)(P(=O)(O)O)P(=O)(O)O.[Na]
• 外观性状: solid | white
• 储存条件: 2-8°C
• 水溶解性: H2O: 28 mg/mL
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:4

  3.氢键受体数量:8

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积167

  7.重原子数量:15

  8.表面电荷:0

  9.复杂度:238

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

• 更多:

  1.熔点（°C）：300

帕米膦酸二钠毒性和生态

帕米膦酸二钠安全信息

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R22:Harmful if swallowed. R48:Danger of serious damage to health by prolonged exposure. R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
• 安全声明 (欧洲): S22:Do not breathe dust . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek m
• WGK德国: 3
• RTECS号: SZ6525000
• 海关编码: 2931900090

帕米膦酸二钠海关

• 海关编码: 2931900090
• 中文概述: 2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
• Summary: 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

帕米膦酸二钠靶点实验

查看更多实验

实验名称：Lipophilicity, log P of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL3624717

实验名称：Mean effective concentration of compound was determined in stimulating Vgamma9 / Vdel... 来源：ChEMBL 靶标：N/A External Id：CHEMBL816011

实验名称：Effective concentration range of compound was determined in stimulating Vgamma9 / Vde... 来源：ChEMBL 靶标：N/A External Id：CHEMBL816010

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Activity against isopentenyl pyrophosphate (IPP) in Vgamma9 / Vdelta2 T cell 来源：ChEMBL 靶标：N/A External Id：CHEMBL816009

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Mean pharmacokinetic parameters for Pamidronate after intravenous infusion of 30, 60 ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL3889452

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帕米膦酸二钠英文别名

• Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]
• Pamidronate disodium salt
• Pamidronate disodium
• Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2)
• Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)]
• APD
• Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate
• MFCD01938386
• EINECS 260-647-1
• (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium
• Pamidronate (Disodium)