57248-88-1

• 常用中文名：帕米膦酸二钠
• 常用英文名：Pamidronate disodium
• CAS号：57248-88-1
• 分子式：C₃H₁₁NNa₂O₇P₂
• 分子量：281.05
• 相关类别： 原料药 水、电解质及酸碱平衡调节药 电解质平衡调节药
• 发布时间：2018-02-24 08:00:00
• 更新时间：2024-01-02 18:32:27
• 【用途一】
  用于高钙血症及骨质疏松症的治疗

名称

• 中文名: 帕米膦酸钠
• 英文名: Disodium Pamidronate Hydrate
• 中文别名: 帕米瞵酸二钠盐; 3-氨基-1-羟基丙亚基-1,1-二磷酸二钠; 帕米膦酸二钠
• 英文别名: Disodium (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogen (phosphonate)]; Pamidronate disodium salt; Pamidronate disodium; Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, sodium salt (1:2); Dinatrium-(3-amino-1-hydroxypropan-1,1-diyl)bis[hydrogen-(phosphonat)]; APD; Disodium (3-amino-1-hydroxy-1-phosphonopropyl)phosphonate; MFCD01938386; EINECS 260-647-1; (3-amino-1-hydroxypropane-1,1-diyl)bis[hydrogène (phosphonate)] de disodium; Pamidronate (Disodium)

物化性质

• 熔点: 300 °C
• 分子式: C₃H₁₁NNa₂O₇P₂
• 分子量: 281.05
• PSA: 186.59000
• 外观性状: solid | white
• 储存条件: 2-8°C
• 水溶解性: H2O: 28 mg/mL
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:4

  3.氢键受体数量:8

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积167

  7.重原子数量:15

  8.表面电荷:0

  9.复杂度:238

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:3

• 更多:

  1.熔点（°C）：300

生物活性

• 描述: Pamidronate二钠盐可强化骨骼。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Zarychanski, R., et al., Osteonecrosis of the jaw associated with pamidronate therapy. Am J Hematol, 2006. 81(1): p. 73-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SZ6525000 CHEMICAL NAME : Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt CAS REGISTRY NUMBER : 57248-88-1 LAST UPDATED : 199709 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C3-H9-N-O7-P2.2Na MOLECULAR WEIGHT : 279.05 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 750 ug/kg/5D-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - visual field changes Sense Organs and Special Senses (Eye) - diplopia Sense Organs and Special Senses (Eye) - effect, not otherwise specified REFERENCE : ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 24,320,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 600 ug/kg/6H-C TOXIC EFFECTS : Nutritional and Gross Metabolic - changes in calcium REFERENCE : LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,622,1987 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 900 ug/kg TOXIC EFFECTS : Musculoskeletal - joints REFERENCE : APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992- Volume(issue)/page/year: 31,499,1997 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1740 mg/kg SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 60 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,654,1992

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R22:Harmful if swallowed. R48:Danger of serious damage to health by prolonged exposure. R41:Risk of serious damage to eyes. R37/38:Irritating to respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
• 安全声明 (欧洲): S22:Do not breathe dust . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek m
• WGK德国: 3
• RTECS号: SZ6525000
• 海关编码: 2931900090

海关

海关编码	2931900090
中文概述	2931900090. 其他有机-无机化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:6.5%. 普通关税:30.0%
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%