R112

• 常用名: R112
• 英文名: R 112
• CAS号: 575474-82-7
• 分子量: 312.29800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₃FN₄O₂
• 熔点: N/A
• 闪点: N/A

R112用途

R112是一种ATP竞争性的Syk激酶抑制剂, Ki值为6 nM. R112抑制Syk激酶活性, IC50值为226 nM。

R112名称

• 中文名: 3,3'-[(5-氟-2,4-嘧啶二基)二亚胺]二[苯酚]
• 英文名: 3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol

R112生物活性

• 描述: R112是一种ATP竞争性的Syk激酶抑制剂, Ki值为6 nM. R112抑制Syk激酶活性, IC50值为226 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> SYK
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Rossi AB, et al. Identification of the Syk kinase inhibitor R112 by a human mast cell screen. J Allergy Clin Immunol. 2006 Sep;118(3):749-755.

  [2]. Meltzer EO, et al. An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment. J Allergy Clin Immunol. 2005 Apr;115(4):791-796.

R112物理化学性质

• 分子式: C₁₆H₁₃FN₄O₂
• 分子量: 312.29800
• 精确质量: 312.10200
• PSA: 93.53000
• LogP: 3.00900
• InChIKey: TVKGTSHBQZEFEE-UHFFFAOYSA-N
• SMILES: Oc1cccc(Nc2ncc(F)c(Nc3cccc(O)c3)n2)c1
• 外观性状: offwhite solid
• 储存条件: 室温

R112靶点实验

查看更多实验

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Inhibition of recombinant Syk 来源：ChEMBL 靶标：Tyrosine-protein kinase SYK External Id：CHEMBL1022010

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Inhibition of SYK 来源：ChEMBL 靶标：Tyrosine-protein kinase SYK External Id：CHEMBL2173408

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FC... 来源：ChEMBL 靶标：Tyrosine-protein kinase SYK External Id：CHEMBL3407019

实验名称：Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-indu... 来源：ChEMBL 靶标：Tyrosine-protein kinase SYK External Id：CHEMBL3407020

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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R112英文别名

• R 112
• R112