24,25-二羟基维生素D2(非对映异构体的混合物)

• 常用名: 24,25-二羟基维生素D2(非对映异构体的混合物)
• 英文名: 24, 25-Dihydroxy VD2
• CAS号: 58050-55-8
• 分子量: 428.64700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₄₄O₃
• 熔点: N/A
• 闪点: N/A

用途

24, 25-Dihydroxy VD2是维生素D2的羟基化代谢产物,是合成的维生素D类似物。

名称

• 中文名: 24,25-二羟基维生素D2
• 英文名: (E,6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2,3-dimethylhept-4-ene-2,3-diol

生物活性

• 描述: 24, 25-Dihydroxy VD2是维生素D2的羟基化代谢产物,是合成的维生素D类似物。
• 相关类别:
  信号通路 >> 维生素 D 相关 >> VD/VDR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. McGraw CA, Hug G. Simultaneous measurement of 25-hydroxy, 24,25-dihydroxy-, and 1,25-dihydroxyvitamin D without use of HPLC. Med Lab Sci. 1990 Jan;47(1):17-25.

  [2]. Katsumi K, Okano T, Ono Y, Maegaki E, Nishimura K, Baba M, Kobayashi T, Miyata O, Naito T, Ninomiya I. Syntheses of 24,25-dihydroxyvitamin D2, 24,25-dihydroxy-22-dehydrovitamin D3, 25-hydroxy-24-oxo-22-dehydrovitamin D3 and 22,24,25-trihydroxyvitamin D3.

  [3]. Horst RL, Littledike ET, Gray RW, Napoli JL. Impaired 24,25-dihydroxyvitamin D production in anephric human and pig. J Clin Invest. 1981 Jan;67(1):274-80.

  [4]. Glenville Jones2, Heinrich K. Schnoes, Leon Levan et al.Isolation and identification of 24-hydroxyvitamin D2 and 24,25-dihydroxyvitamin D2. Archives of Biochemistry and Biophysics.Volume 202, Issue 2, July 1980, Pages 450-457

  [5]. Glenville Jones, Alan Rosenthal,David Segev et al. Isolation and identification of 24,25-dihydroxy vitamin D2 by use of the perfused rat kidney. Biochemistry, 1979, 18 (6), pp 1094-1101

物理化学性质

• 分子式: C₂₈H₄₄O₃
• 分子量: 428.64700
• 精确质量: 428.32900
• PSA: 60.69000
• LogP: 5.87080
• InChIKey: BPEQZNMKGFTMQE-YWGACSKASA-N
• SMILES: C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)C=CC(C)(O)C(C)(C)O
• 储存条件: 2-8℃

英文别名

• (4E,6R)-2,3-Dimethyl-6-[(1R,3aS,4E,7aR)-octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-7a-methyl-1H-inden-1-yl]-4-heptene-2,3-diol
• 24,25-Dihydroxy VD2
• 24,25-Dihydroxy Vitamin D2
• (3|A,5Z,7E,22E,24|I)-9,10-Secoergosta-5,7,10(19),22-tetraene-3,24,25-triol
• (24R)-24,25-dihydroxyvitamin D2
• 24(S),25-dihydroxyvitamin D2
• CS-0802
• 24, 25-Dihydroxy VD2