Sorafenib N-Oxide

• 常用名: Sorafenib N-Oxide
• 英文名: Sorafenib N-Oxide
• CAS号: 583840-03-3
• 分子量: 483.84300
• 密度: 1.455g/cm3
• 沸点: 591.655ºC at 760 mmHg
• 分子式: C₂₁H₁₃ClD₃F₃N₄O₄
• 熔点: 220-222ºC
• 闪点: 311.622ºC

Sorafenib N-Oxide用途

Sorafenib N-oxide is an active metabolite of sorafenib (BAY 43-9006), an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD. It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3. Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4.

Sorafenib N-Oxide名称

• 英文名: Sorafenib N-Oxide

Sorafenib N-Oxide物理化学性质

• 密度: 1.455g/cm3
• 沸点: 591.655ºC at 760 mmHg
• 熔点: 220-222ºC
• 分子式: C₂₁H₁₃ClD₃F₃N₄O₄
• 分子量: 483.84300
• 闪点: 311.622ºC
• 精确质量: 483.10000
• PSA: 104.92000
• LogP: 6.12010
• InChIKey: BQAZCCVUZDIZDC-UHFFFAOYSA-N
• SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)cc[n+]1[O-]
• 折射率: 1.601

Sorafenib N-Oxide英文别名

• 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-1-oxidopyridin-1-ium-2-carboxamide