Sorafenib N-Oxide

Modify Date: 2024-01-05 18:59:04

Sorafenib N-Oxide Structure
Sorafenib N-Oxide structure
Common Name Sorafenib N-Oxide
CAS Number 583840-03-3 Molecular Weight 483.84300
Density 1.455g/cm3 Boiling Point 591.655ºC at 760 mmHg
Molecular Formula C21H13ClD3F3N4O4 Melting Point 220-222ºC
MSDS N/A Flash Point 311.622ºC

 Use of Sorafenib N-Oxide


Sorafenib N-oxide is an active metabolite of sorafenib (BAY 43-9006), an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD. It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3. Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4.

 Names

Name Sorafenib N-Oxide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.455g/cm3
Boiling Point 591.655ºC at 760 mmHg
Melting Point 220-222ºC
Molecular Formula C21H13ClD3F3N4O4
Molecular Weight 483.84300
Flash Point 311.622ºC
Exact Mass 483.10000
PSA 104.92000
LogP 6.12010
Index of Refraction 1.601

 Synthetic Route

~55%

Sorafenib N-Oxide Structure

Sorafenib N-Oxide

CAS#:583840-03-3

Literature: BAYER CORPORATION Patent: US2003/216446 A1, 2003 ; US 20030216446 A1

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-1-oxidopyridin-1-ium-2-carboxamide
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