583840-03-3

• 常用中文名：索拉非尼氮氧化合物
• 常用英文名：Sorafenib N-Oxide
• CAS号：583840-03-3
• 分子式：C₂₁H₁₃ClD₃F₃N₄O₄
• 分子量：483.84300
• 发布时间：2017-07-21 15:14:10
• 更新时间：2025-08-31 10:15:55
• Sorafenib N-oxide is an active metabolite of sorafenib (BAY 43-9006), an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD. It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3. Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4.

名称

• 中文名: 索拉非尼氮氧化合物
• 英文名: Sorafenib N-Oxide
• 中文别名: 索拉非尼杂质(索拉非尼N氧化物); 索拉非尼N氧化物; 4-(4-(3-(4-氯-3-(三氟甲基)苯基)脲基)苯氧基)-2-(甲基氨基甲酰基)吡啶 1-氧化物; 索拉非尼杂质27(索拉非尼氮氧化物); 索拉非尼N氧化杂质; 索拉非尼杂质; 索拉非尼杂质02; 索拉非尼氮氧化物
• 英文别名: 2-Pyridinecboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 1-oxide; Sorafenib N-oxide; Sorafenib impurities172; 4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-Methyl-2-pyridinecboxaMide 1-Oxide; Sorafenib impurity 23/Sorafenib N-Oxide/4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcbamoyl)pyridine 1-oxide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-1-oxidopyridin-1-ium-2-carboxamide; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-2-(methylcbamoyl)pyridine 1-oxide; Sorafenib Impurity 27(Sorafenib N-Oxide); Sorafenib impurities11

物化性质

• 密度: 1.455g/cm3
• 沸点: 591.655ºC at 760 mmHg
• 熔点: 220-222ºC
• 分子式: C₂₁H₁₃ClD₃F₃N₄O₄
• 分子量: 483.84300
• 闪点: 311.622ºC
• 精确质量: 483.10000
• PSA: 104.92000
• LogP: 6.12010
• 折射率: 1.601

合成路线

284461-73-0 ~55% 583840-03-3

文献：BAYER CORPORATION Patent: US2003/216446 A1, 2003 ; US 20030216446 A1

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