去甲乌头碱

• 常用名: 去甲乌头碱
• 英文名: Higenamine
• CAS号: 5843-65-2
• 分子量: 271.311
• 密度: 1.3±0.1 g/cm3
• 沸点: 522.4±50.0 °C at 760 mmHg
• 分子式: C₁₆H₁₇NO₃
• 熔点: 208-210℃
• 闪点: 209.6±20.7 °C

去甲乌头碱用途

Higenamine (Norcoclaurine) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine (Norcoclaurine) 具有抗凋亡作用。

去甲乌头碱名称

• 中文名: 去甲基衡州乌药碱
• 英文名: (RS)-norcoclaurine
• 中文别名: 去甲乌药碱

去甲乌头碱生物活性

• 描述: Higenamine (Norcoclaurine) 是一种 β2-AR 激动剂,是东亚国家治疗心力衰竭的中药乌头的关键成分。Higenamine (Norcoclaurine) 具有抗凋亡作用。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 内分泌
• 靶点实验:

  β2-AR[1]

• 参考文献:

  [1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23.

  [2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148.

去甲乌头碱物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 522.4±50.0 °C at 760 mmHg
• 熔点: 208-210℃
• 分子式: C₁₆H₁₇NO₃
• 分子量: 271.311
• 闪点: 209.6±20.7 °C
• 精确质量: 271.120850
• PSA: 72.72000
• LogP: 1.41
• InChIKey: WZRCQWQRFZITDX-UHFFFAOYSA-N
• SMILES: Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.666
• 储存条件: 库房低温,通风,干燥

去甲乌头碱毒性和生态

去甲乌头碱靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Potency was measured by the displacement of [3H]spiperone binding to human D2 dopamin... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL670395

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Inhibition of MAO (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL5224066

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Inhibition of LSD1 (unknown origin) 来源：ChEMBL 靶标：Lysine-specific histone demethylase 1A External Id：CHEMBL5224065

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Agonist activity at beta2 adrenergic receptor in rat L6 cell lysate assessed as incre... 来源：ChEMBL 靶标：Beta-2 adrenergic receptor External Id：CHEMBL4180557

共31条，当前第1页，共4页

1

2

3

4

去甲乌头碱英文别名

• Higenamine
• 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisochinolin-6,7-diol
• (R,S)-norcoclaurine
• (+-)-O-Demethylcoclaurine
• Coclaurine,O-demethyl-,(+-)
• 1-(p-hydroxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
• (+-)-Demethylcoclaurine
• rac-norcoclaurine
• 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol
• (±)-HIGENAMINE
• Norcoclaurine
• 1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
• 1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
• UNII:TBV5O16GAP
• 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-,(+-)