Higenamine
Higenamine structure
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Common Name | Higenamine | ||
|---|---|---|---|---|
| CAS Number | 5843-65-2 | Molecular Weight | 271.311 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 522.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H17NO3 | Melting Point | 208-210℃ | |
| MSDS | N/A | Flash Point | 209.6±20.7 °C | |
Use of HigenamineHigenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine (Norcoclaurine) has anti-apoptotic effects[1][2]. |
Summary: (RS)-norcoclaurine, also known as Higenamine, Chinese name is 去甲基衡州乌药碱 or 去甲乌头碱, has a CAS number of 5843-65-2, molecular formula of C16H17NO3, and molecular weight of 271.311. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | (RS)-norcoclaurine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Higenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine (Norcoclaurine) has anti-apoptotic effects[1][2]. |
|---|---|
| Related Catalog | |
| Target |
β2-AR[1] |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 522.4±50.0 °C at 760 mmHg |
| Melting Point | 208-210℃ |
| Molecular Formula | C16H17NO3 |
| Molecular Weight | 271.311 |
| Flash Point | 209.6±20.7 °C |
| Exact Mass | 271.120850 |
| PSA | 72.72000 |
| LogP | 1.41 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.666 |
| InChIKey | WZRCQWQRFZITDX-UHFFFAOYSA-N |
| SMILES | Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1 |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Higenamine CAS#:5843-65-2 |
| Literature: Pesnot, Thomas; Gershater, Markus C.; Ward, John M.; Hailes, Helen C. Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 2997 - 3008 |
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Higenamine CAS#:5843-65-2 |
| Literature: Advanced Synthesis and Catalysis, , vol. 354, # 16 p. 2997 - 3008 |
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~%
Higenamine CAS#:5843-65-2 |
| Literature: Advanced Synthesis and Catalysis, , vol. 354, # 16 p. 2997 - 3008 |
|
~%
Higenamine CAS#:5843-65-2 |
| Literature: Advanced Synthesis and Catalysis, , vol. 354, # 16 p. 2997 - 3008 |
|
~%
Higenamine CAS#:5843-65-2 |
| Literature: Advanced Synthesis and Catalysis, , vol. 354, # 16 p. 2997 - 3008 |
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~%
Higenamine CAS#:5843-65-2 |
| Literature: Advanced Synthesis and Catalysis, , vol. 354, # 16 p. 2997 - 3008 |
![(1S)-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-2-((1S)-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline structure](https://image.chemsrc.com/caspic/399/1421820-28-1.png)
amine structure](https://image.chemsrc.com/caspic/238/114105-51-0.png)
![N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide structure](https://image.chemsrc.com/caspic/437/1421820-27-0.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 0 | |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Higenamine |
| 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisochinolin-6,7-diol |
| (R,S)-norcoclaurine |
| (+-)-O-Demethylcoclaurine |
| Coclaurine,O-demethyl-,(+-) |
| 1-(p-hydroxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline |
| (+-)-Demethylcoclaurine |
| rac-norcoclaurine |
| 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol |
| (±)-HIGENAMINE |
| Norcoclaurine |
| 1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol |
| 1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol |
| UNII:TBV5O16GAP |
| 6,7-Isoquinolinediol,1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-,(+-) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of (RS)-norcoclaurine? |
| A: Boiling point of (RS)-norcoclaurine is 522.4±50.0 °C at 760 mmHg. |
| Q: What is the English name of (RS)-norcoclaurine? |
| A: The English name of (RS)-norcoclaurine is (RS)-norcoclaurine. |
| Q: What is the melting point of (RS)-norcoclaurine? |
| A: Melting point of (RS)-norcoclaurine is 208-210℃. |
| Q: What is the CAS number of (RS)-norcoclaurine? |
| A: CAS number of (RS)-norcoclaurine is 5843-65-2. |
| Q: What is the InChIKey of (RS)-norcoclaurine? |
| A: InChIKey of (RS)-norcoclaurine is WZRCQWQRFZITDX-UHFFFAOYSA-N. |
| Q: What is the molecular formula of (RS)-norcoclaurine? |
| A: Molecular formula of (RS)-norcoclaurine is C16H17NO3. |
| Q: What is the SMILES notation of (RS)-norcoclaurine? |
| A: SMILES notation of (RS)-norcoclaurine is Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1. |
| Q: What are the upstream materials of (RS)-norcoclaurine? |
| A: Related upstream materials(CAS) of (RS)-norcoclaurine: 51-61-6;7339-87-9;1421820-28-1;93-40-3;114105-64-5;114105-51-0;1421820-27-0. |
| Q: What is the molecular weight of (RS)-norcoclaurine? |
| A: Molecular weight of (RS)-norcoclaurine is 271.311. |
| Q: What are the uses of (RS)-norcoclaurine? |
| A: Main uses of (RS)-norcoclaurine: Higenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine (Norcoclaurine) has anti-apoptotic effects[1][2]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| naturewill |