AHR-5333

• 常用名: AHR-5333
• 英文名: AHR-5333
• CAS号: 60284-71-1
• 分子量: 509.58400
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₃F₂NO₄
• 熔点: N/A
• 闪点: N/A

AHR-5333用途

AHR-5333 是一种选择性人血液中性粒细胞5-脂氧合酶(5-lipoxygenase)抑制剂。AHR-5333在大鼠和豚鼠体内急性超敏反应模型中表现出有效的长效活性。

AHR-5333名称

• 英文名: 1-[4-[3-[4-[bis(4-fluorophenyl)-hydroxymethyl]piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone

AHR-5333生物活性

• 描述: AHR-5333 是一种选择性人血液中性粒细胞5-脂氧合酶(5-lipoxygenase)抑制剂。AHR-5333在大鼠和豚鼠体内急性超敏反应模型中表现出有效的长效活性。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶
• 靶点实验:

  60284-71-1

• 参考文献:

  [1]. J M Yanni, et al. Effects of AHR-5333, a new potential antiallergy compound, in in vivo models of immediate hypersensitivity. Int Arch Allergy Appl Immunol. 1988;85(4):428-33.

  [2]. G. Graff, et al. 1-[4-[3-[4-[Bis (4-fluorophenyl) hydroxymethyl]-1-piperidinyl] propoxy]-3]-methoxyphenyl] ethanone (AHR-5333): A selective human blood neutrophil 5-lipoxygenase inhibitor. Prostaglandins. Volume 38, Issue 4, October 1989, Pages 473-496

AHR-5333物理化学性质

• 分子式: C₃₀H₃₃F₂NO₄
• 分子量: 509.58400
• 精确质量: 509.23800
• PSA: 59.00000
• LogP: 5.53090
• InChIKey: QFUKWQQHSSRPQM-UHFFFAOYSA-N
• SMILES: COc1cc(C(C)=O)ccc1OCCCN1CCC(C(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1

AHR-5333靶点实验

查看更多实验

实验名称：Oral antiallergy activity in the guinea pig anaphylaxis (GPA) model, at a pretreatmen... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685709

实验名称：Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a do... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL793150

实验名称：Calcium channel-blocking activity by determined by ability to antagonize calcium-indu... 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL772790

实验名称：Oral antiallergy activity in the guinea pig anaphylaxis (GPA) model of, at a pretreat... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL877785

实验名称：Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a do... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL791604

实验名称：Antihypertensive activity expressed as change in mean arterial blood pressure (MABP) ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL775998

实验名称：Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a do... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL791609

实验名称：Antihypertensive activity expressed as change in mean arterial blood pressure (MABP) ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL775997

实验名称：Inhibitory activity against Tritiated [3H]- mepyramine binding to histamine H1 recept... 来源：ChEMBL 靶标：Histamine H1 receptor External Id：CHEMBL693832

实验名称：Oral antiallergy activity in the guinea pig anaphylaxis (GPA) model, at a pretreatmen... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685708

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AHR-5333英文别名

• Ahr 5333