比沙可啶

• 常用名: 比沙可啶
• 英文名: Bisacodyl
• CAS号: 603-50-9
• 分子量: 361.39100
• 密度: 1.2 g/cm3
• 沸点: 492ºC
• 分子式: C₂₂H₁₉NO₄
• 熔点: 131 - 135ºC
• 闪点: N/A
• 符号: GHS07
• 信号词: Warning

比沙可啶用途

Bisacodyl是刺激性泻剂,能直接刺激结肠产生排便活动。

比沙可啶名称

• 中文名: 比沙可啶
• 英文名: Bisacodyl
• 中文别名: 盐酸普鲁卡因 | 双醋苯啶 | 4,4'-(2-吡啶亚甲基)双酚二乙酸酯

比沙可啶生物活性

• 描述: Bisacodyl是刺激性泻剂,能直接刺激结肠产生排便活动。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Ikarashi, N., et al., The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol, 2011. 301(5): p. G887-95.

  [2]. Saunders, D.R., et al., Effect of bisacodyl on the structure and function of rodent and human intestine. Gastroenterology, 1977. 72(5 Pt 1): p. 849-56.

  [3]. Karmeli, F., R. Stalnikowicz, and D. Rachmilewitz, Effect of colchicine and bisacodyl on rat intestinal transit and nitric oxide synthase activity. Scand J Gastroenterol, 1997. 32(8): p. 791-6.

  [4]. Rachmilewitz, D., F. Karmeli, and E. Okon, Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na + K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestine. Dig Dis Sci, 1980. 25(8): p. 602-8.

  [5]. Borrelli, F., et al., Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon. Life Sci, 2001. 69(16): p. 1871-7.

比沙可啶物理化学性质

• 密度: 1.2 g/cm3
• 沸点: 492ºC
• 熔点: 131 - 135ºC
• 分子式: C₂₂H₁₉NO₄
• 分子量: 361.39100
• 精确质量: 361.13100
• PSA: 65.49000
• LogP: 4.11240
• InChIKey: KHOITXIGCFIULA-UHFFFAOYSA-N
• SMILES: CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1
• 外观性状: 白色至灰白色结晶粉末
• 储存条件: 2-8°C
• 稳定性: Stable. Incompatible with strong oxidizing agents.
• 计算化学:

  1.疏水参数计算参考值（XlogP）:3.8

  2.氢键供体数量:0

  3.氢键受体数量:5

  4.可旋转化学键数量:7

  5.互变异构体数量:无

  6.拓扑分子极性表面积:65.5

  7.重原子数量:27

  8.表面电荷:0

  9.复杂度:457

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

比沙可啶MSDS

比沙可啶MSDS英文版

比沙可啶毒性和生态

比沙可啶安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H315-H319-H335
• 警示性声明: P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xi:Irritant
• 风险声明 (欧洲): R22;R36/37/38
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: SM8750000
• 海关编码: 2942000000

比沙可啶海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

比沙可啶靶点实验

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实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

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比沙可啶英文别名

• LA96A
• laco
• neolax
• zetrax
• durolax
• laxine
• EINECS 210-044-4
• MFCD00038039
• ivilax
• Bicol
• deficol
• Laxans