吡那地尔

• 常用名: 吡那地尔
• 英文名: Pinacidil
• CAS号: 60560-33-0
• 分子量: 245.32300
• 密度: 1.1402 (rough estimate)
• 沸点: 378.29°C (rough estimate)
• 分子式: C₁₃H₁₉N₅
• 熔点: 110-114℃
• 闪点: N/A

吡那地尔用途

吡那地尔是钾通道的有效激活剂。吡那地尔是一种抗高血压药物,通过开放K+通道使血管平滑肌超极化。吡那地尔显著改善再灌注功能和心脏顺应性。吡那地尔具有直接的心脏保护功效[1]。

吡那地尔名称

• 中文名: 吡那地尔
• 英文名: pinacidil
• 中文别名: (+/-)-N-氰基-N'-4-吡啶基-N''-(1,2,2-三甲基丙基)胍

吡那地尔生物活性

• 描述: 吡那地尔是钾通道的有效激活剂。吡那地尔是一种抗高血压药物,通过开放K+通道使血管平滑肌超极化。吡那地尔显著改善再灌注功能和心脏顺应性。吡那地尔具有直接的心脏保护功效[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  potassium channel[1]

• 参考文献:

  [1]. Grover GJ, et al. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther. 1989;251(1):98-104.

  [2]. Hamilton TC, et al. Cromakalim, nicorandil and pinacidil: novel drugs which open potassium channels in smooth muscle. Gen Pharmacol. 1989;20(1):1-9.

吡那地尔物理化学性质

• 密度: 1.1402 (rough estimate)
• 沸点: 378.29°C (rough estimate)
• 熔点: 110-114℃
• 分子式: C₁₃H₁₉N₅
• 分子量: 245.32300
• 精确质量: 245.16400
• PSA: 73.10000
• LogP: 2.81868
• InChIKey: IVVNZDGDKPTYHK-UHFFFAOYSA-N
• SMILES: CC(N=C(NC#N)Nc1ccncc1)C(C)(C)C
• 外观性状: solid | white
• 折射率: 1.6500 (estimate)
• 水溶解性: ethanol: 14 mg/mL

吡那地尔毒性和生态

吡那地尔安全信息

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22-36/37/38
• 安全声明 (欧洲): 36
• WGK德国: 3
• 海关编码: 2933399090

吡那地尔海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吡那地尔靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree... 来源：824 靶标：N/A External Id：P53600

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吡那地尔英文别名

• p1134
• pinacidilmonohydrate
• 2-cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)guanidinemonohydrate
• (+/-)-Pinacidil
• 2-Cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)guanidine
• s-1230
• 2-cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)-guanidinmonohydrate
• N"-cyano-N-4-pyridyl-N'-1,2,2,trimethyl propylguanidine
• (+/-)-N-CYANO-N'-4-PYRIDINYL-N''-(1,2,2-TRIMETHYLPROPYL)GUANIDINE
• Picacidil