甘草黄酮A

• 常用名: 甘草黄酮A
• 英文名: Licoflavone A
• CAS号: 61153-77-3
• 分子量: 322.35500
• 密度: 1.279±0.06 g/cm3(Predicted)
• 沸点: 551.1±50.0 °C(Predicted)
• 分子式: C₂₀H₁₈O₄
• 熔点: N/A
• 闪点: N/A

甘草黄酮A用途

Licoflavone A 是从甘草根中得到的黄酮类化合物,抑制酪氨酸磷酸酶 1B (PTP1B) 的活性,IC50 值为 54.5 μM。

甘草黄酮A名称

• 中文名: 甘草黄酮A
• 英文名: Licoflavone A

甘草黄酮A生物活性

• 描述: Licoflavone A 是从甘草根中得到的黄酮类化合物,抑制酪氨酸磷酸酶 1B (PTP1B) 的活性,IC50 值为 54.5 μM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 54.5 μM (PTP1B)[1]

• 参考文献:

  [1]. Li S, et al. Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401.

甘草黄酮A物理化学性质

• 密度: 1.279±0.06 g/cm3(Predicted)
• 沸点: 551.1±50.0 °C(Predicted)
• 分子式: C₂₀H₁₈O₄
• 分子量: 322.35500
• 精确质量: 322.12100
• PSA: 70.67000
• LogP: 4.37990
• InChIKey: HJGURBGBPIKRER-UHFFFAOYSA-N
• SMILES: CC(C)=CCc1cc2c(=O)cc(-c3ccc(O)cc3)oc2cc1O
• 外观性状: 粉末
• 储存条件: 2-8°C，密封，干燥

甘草黄酮A靶点实验

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实验名称：Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 1... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL4035961

实验名称：Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4035959

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4035957

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186600

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046717

实验名称：Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4035954

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186601

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186602

实验名称：Inhibition of recombinant human PTP1B assessed as hydrolysis of p-nitrophenyl phospha... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL3810645

实验名称：Antitussive activity in ammonia liquor-induced cough ICR mouse model assessed as redu... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4186611

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甘草黄酮A英文别名

• 7-Hydroxy-2-(4-hydroxy-phenyl)-6-(3-methyl-but-2-enyl)-chromen-4-one
• licoflavone A
• Licoflavon-A
• licoflavanone A