五味子乙素

• 常用名: 五味子乙素
• 英文名: Schizandrin B
• CAS号: 61281-37-6
• 分子量: 400.465
• 密度: 1.1±0.1 g/cm3
• 沸点: 545.0±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈O₆
• 熔点: N/A
• 闪点: 220.4±30.0 °C

五味子乙素用途

五味子乙素(Wuweizisu-B)是从五味子中分离联苯环辛二烯衍生物,已被证明对啮齿类动物的肝脏和心脏的抗氧化作用。

五味子乙素名称

• 中文名: 五味子乙素
• 英文名: Schisandrin B
• 中文别名: 五味子素乙

五味子乙素生物活性

• 描述: 五味子乙素(Wuweizisu-B)是从五味子中分离联苯环辛二烯衍生物,已被证明对啮齿类动物的肝脏和心脏的抗氧化作用。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  研究领域 >> 神经疾病
  天然产物 >> 苯丙酸类
• 参考文献:

  [1]. Checker R, et al. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. Free Radic Biol Med. 2012 Oct 1;53(7):1421-30.

  [2]. Lam PY, et al. Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases. Oxid Med Cell Longev. 2012;2012:250825.

  [3]. Zeng KW, et al. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol. 2012 Oct 5;692(1-3):29-37.

  [4]. Liu Z, et al. Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition. PLoS One. 2012;7(7):e40480.

  [5]. Zhu S, et al. Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo. Am J Chin Med. 2012;40(3):551-66.

五味子乙素物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 545.0±50.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈O₆
• 分子量: 400.465
• 闪点: 220.4±30.0 °C
• 精确质量: 400.188599
• PSA: 55.38000
• LogP: 6.46
• InChIKey: RTZKSTLPRTWFEV-OLZOCXBDSA-N
• SMILES: COc1cc2c(c(OC)c1OC)-c1c(cc3c(c1OC)OCO3)CC(C)C(C)C2
• 外观性状: 固体
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.543
• 储存条件: 室温

五味子乙素毒性和生态

五味子乙素安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2942000000

五味子乙素海关

• 海关编码: 2942000000

五味子乙素靶点实验

查看更多实验

实验名称：TP_TRANSPORTER: inhibition of VCR transport in HL60/MRP cells 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL2077107

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：TP_TRANSPORTER: inhibition of VCR transport in HL60/ADR cells (overexpression of MRP1... 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL2077108

实验名称：TP_TRANSPORTER: inhibition of VP-16 transport in HL60/MRP cells 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL2077105

实验名称：TP_TRANSPORTER: inhibition of DNR transport in HL60/ADR cells (overexpression of MRP1... 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL2077838

实验名称：TP_TRANSPORTER: inhibition of VP-16 transport in HL60/ADR cells (overexpression of MR... 来源：ChEMBL 靶标：Multidrug resistance-associated protein 1 External Id：CHEMBL2077106

实验名称：Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incor... 来源：ChEMBL 靶标：Serine/threonine-protein kinase ATR External Id：CHEMBL1767585

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Inhibition of P-gp in human KBv200 cells assessed as potentiation of vincristine-indu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4264822

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

共24条，当前第1页，共3页

1

2

3

五味子乙素英文别名

• MFCD00210555
• GEMA-SCHIZANDRIN
• 1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxole
• Schisandrin B