沃拉帕沙

• 常用名: 沃拉帕沙
• 英文名: Vorapaxar
• CAS号: 618385-01-6
• 分子量: 492.582
• 密度: 1.3±0.1 g/cm3
• 沸点: 676.0±55.0 °C at 760 mmHg
• 分子式: C₂₉H₃₃FN₂O₄
• 熔点: N/A
• 闪点: 362.6±31.5 °C

沃拉帕沙用途

Vorapaxar是凝血酶受体（蛋白酶活化受体，PAR-1）拮抗剂。

沃拉帕沙名称

• 中文名: 维拉帕莎硫酸盐
• 英文名: vorapaxar
• 中文别名: 沃拉帕沙

沃拉帕沙生物活性

• 描述: Vorapaxar是一种蛋白酶激活受体 (PAR-1)拮抗剂,可抑制凝血酶诱导的血小板活化。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 蛋白酶激活受体(PAR)
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Khoufache K, et al. PAR1 contributes to influenza A virus pathogenicity in mice. J Clin Invest. 2013 Jan;123(1):206-14.

  [2]. Kehinde O, et al. Vorapaxar: A novel agent to be considered in the secondary prevention of myocardial infarction. J Pharm Bioallied Sci. 2016 Apr-Jun;8(2):98-105.

沃拉帕沙物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 676.0±55.0 °C at 760 mmHg
• 分子式: C₂₉H₃₃FN₂O₄
• 分子量: 492.582
• 闪点: 362.6±31.5 °C
• 精确质量: 492.242432
• PSA: 81.01000
• LogP: 4.54
• InChIKey: ZBGXUVOIWDMMJE-QHNZEKIYSA-N
• SMILES: CCOC(=O)NC1CCC2C(C1)CC1C(=O)OC(C)C1C2C=Cc1ccc(-c2cccc(F)c2)cn1
• 外观性状: 白色至类白色固体
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.594
• 储存条件: -20℃

沃拉帕沙靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Cytotoxicity against human HepG2 cells assessed as ATP contents at 30 uM after 24 hrs... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL3095277

实验名称：Antagonist activity at PAR1 in human platelet rich plasma assessed as inhibition of h... 来源：ChEMBL 靶标：Proteinase-activated receptor 1 External Id：CHEMBL3095278

实验名称：Antagonist activity at PAR1 in washed human platelets assessed as inhibition of haTRA... 来源：ChEMBL 靶标：Proteinase-activated receptor 1 External Id：CHEMBL3095279

实验名称：Displacement of [3H]haTRAP from PAR1 in human platelet membranes after 60 mins by sci... 来源：ChEMBL 靶标：Proteinase-activated receptor 1 External Id：CHEMBL3095280

实验名称：Metabolic stability in human liver microsomes assessed as time when 50% of compound r... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3095281

实验名称：Incucyte cell viability with HEK293T 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL5058565

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沃拉帕沙英文别名

• Carbamic acid, [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2- pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
• Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
• Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
• Vorapaxar
• UNII-ZCE93644N2
• ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
• Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2- pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-y l]carbamate
• Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate