AFN-1252

更新时间：2025-08-29 17:14:53

AFN-1252结构式	常用名	AFN-1252	英文名	AFN-1252
	CAS号	620175-39-5	分子量	375.42000
	密度	N/A	沸点	N/A
	分子式	C₂₂H₂₁N₃O₃	熔点	N/A
	MSDS	N/A	闪点	N/A

AFN-1252用途

AFN-1252(Debio 1452)是FabI高效抑制剂，能抑制金黄色葡萄球菌。

中文名	AFN-1252
英文名	(E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide
英文别名	更多

描述	AFN-1252(Debio 1452)是FabI高效抑制剂,能抑制金黄色葡萄球菌。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 感染
参考文献	[1]. Karlowsky JA, et al. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8. [2]. Narasimha Rao K, et al. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei-Crystal structure, mode of action, and biological activity. Protein Sci. 2015 May;24(5):832-40. [3]. Yao J, et al. Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71. [4]. Parsons JB, et al. Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother. 2013 May;57(5):2182-90.

描述

AFN-1252(Debio 1452)是FabI高效抑制剂,能抑制金黄色葡萄球菌。

相关类别

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

参考文献

[1]. Karlowsky JA, et al. AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. Antimicrob Agents Chemother. 2009 Aug;53(8):3544-8.

[2]. Narasimha Rao K, et al. AFN-1252 is a potent inhibitor of enoyl-ACP reductase from Burkholderia pseudomallei-Crystal structure, mode of action, and biological activity. Protein Sci. 2015 May;24(5):832-40.

[3]. Yao J, et al. Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI). J Biol Chem. 2013 Dec 20;288(51):36261-71.

[4]. Parsons JB, et al. Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252. Antimicrob Agents Chemother. 2013 May;57(5):2182-90.

分子式	C₂₂H₂₁N₃O₃
分子量	375.42000
精确质量	375.15800
PSA	78.93000
LogP	3.77780
InChIKey	QXTWSUQCXCWEHF-JXMROGBWSA-N
SMILES	Cc1c(CN(C)C(=O)C=Cc2cnc3c(c2)CCC(=O)N3)oc2ccccc12
储存条件	2-8℃

实验名称：Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213...
来源：ChEMBL
靶标：Staphylococcus aureus
External Id：CHEMBL3365685

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591...
来源：ChEMBL
靶标：Staphylococcus aureus
External Id：CHEMBL3365686

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
来源：NCGC
External Id：IP6K1-p1

实验名称：Inhibition of Staphylococcus aureus FabI-mediated reduction of enoyl-ACP preincubated...
来源：ChEMBL
靶标：Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
External Id：CHEMBL3365683

实验名称：Metabolic stability in mouse liver mirosomes assessed as compound remaining at 1 uM a...
来源：ChEMBL
靶标：Liver
External Id：CHEMBL3365689

实验名称：AUC in Swiss albino CD-1 mouse at 10 mg/kg, po administered as single dose
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL3365690

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus epidermidis AUCC ...
来源：ChEMBL
靶标：Staphylococcus epidermidis
External Id：CHEMBL3365687

实验名称：Metabolic stability in mouse liver mirosomes assessed as compound remaining at 1 uM a...
来源：ChEMBL
靶标：Liver
External Id：CHEMBL3365688

实验名称：Tmax in Swiss albino CD-1 mouse at 10 mg/kg, po administered as single dose
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL3365693

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