7-氨基-4-氯-3-甲氧基异香豆素

• 常用名: 7-氨基-4-氯-3-甲氧基异香豆素
• 英文名: JLK 6
• CAS号: 62252-26-0
• 分子量: 225.62800
• 密度: 1.46g/cm3
• 沸点: 456.1ºC at 760 mmHg
• 分子式: C₁₀H₈ClNO₃
• 熔点: 115 °C
• 闪点: 229.7ºC

7-氨基-4-氯-3-甲氧基异香豆素用途

JLK-6通过影响淀粉样β前体蛋白(APP)表达的HEK293细胞的γ-分泌酶切割,显著减少淀粉样β-肽(Aβ)的生成,而不影响Notch受体的切割[1]。

7-氨基-4-氯-3-甲氧基异香豆素名称

• 中文名: 7-氨基-4-氯-3-甲氧基异香豆素
• 英文名: 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran

7-氨基-4-氯-3-甲氧基异香豆素生物活性

• 描述: JLK-6通过影响淀粉样β前体蛋白(APP)表达的HEK293细胞的γ-分泌酶切割,显著减少淀粉样β-肽(Aβ)的生成,而不影响Notch受体的切割[1]。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21(4):1018-29.

7-氨基-4-氯-3-甲氧基异香豆素物理化学性质

• 密度: 1.46g/cm3
• 沸点: 456.1ºC at 760 mmHg
• 熔点: 115 °C
• 分子式: C₁₀H₈ClNO₃
• 分子量: 225.62800
• 闪点: 229.7ºC
• 精确质量: 225.01900
• PSA: 65.46000
• LogP: 2.61840
• InChIKey: AMDGKLWVCUXONP-UHFFFAOYSA-N
• SMILES: COc1oc(=O)c2cc(N)ccc2c1Cl
• 外观性状: 棕色固体
• 折射率: 1.628
• 储存条件: 2-8°C，避光，密封

7-氨基-4-氯-3-甲氧基异香豆素安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2932999099

7-氨基-4-氯-3-甲氧基异香豆素海关

• 海关编码: 2932999099
• 中文概述: 2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-氨基-4-氯-3-甲氧基异香豆素靶点实验

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7-氨基-4-氯-3-甲氧基异香豆素英文别名

• 7-amino-3-methoxy-4-chloroisocoumarin
• 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
• 7-Amino-4-chlor-3-methoxyisocumarin
• 3-methoxy-4-chloro-7-aminoisocoumarin
• 7-amino-4-chloro-3-methoxy-isochromen-1-one