JLK 6

Modify Date: 2025-08-25 16:17:33

JLK 6 Structure
JLK 6 structure
Common Name JLK 6
CAS Number 62252-26-0 Molecular Weight 225.62800
Density 1.46g/cm3 Boiling Point 456.1ºC at 760 mmHg
Molecular Formula C10H8ClNO3 Melting Point 115 °C
MSDS N/A Flash Point 229.7ºC

 Use of JLK 6


JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].

 Names

Name 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Synonym More Synonyms

 JLK 6 Biological Activity

Description JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].
Related Catalog
References

[1]. Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21(4):1018-29.

 Chemical & Physical Properties

Density 1.46g/cm3
Boiling Point 456.1ºC at 760 mmHg
Melting Point 115 °C
Molecular Formula C10H8ClNO3
Molecular Weight 225.62800
Flash Point 229.7ºC
Exact Mass 225.01900
PSA 65.46000
LogP 2.61840
Index of Refraction 1.628
InChIKey AMDGKLWVCUXONP-UHFFFAOYSA-N
SMILES COc1oc(=O)c2cc(N)ccc2c1Cl

 Safety Information

Hazard Codes Xi
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

7-amino-3-methoxy-4-chloroisocoumarin
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
7-Amino-4-chlor-3-methoxyisocumarin
3-methoxy-4-chloro-7-aminoisocoumarin
7-amino-4-chloro-3-methoxy-isochromen-1-one
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