JLK 6

Modify Date: 2024-01-13 16:36:02

JLK 6 Structure
JLK 6 structure
Common Name JLK 6
CAS Number 62252-26-0 Molecular Weight 225.62800
Density 1.46g/cm3 Boiling Point 456.1ºC at 760 mmHg
Molecular Formula C10H8ClNO3 Melting Point 115 °C
MSDS N/A Flash Point 229.7ºC

 Use of JLK 6


JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].

 Names

Name 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
Synonym More Synonyms

 JLK 6 Biological Activity

Description JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].
Related Catalog
References

[1]. Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21(4):1018-29.

 Chemical & Physical Properties

Density 1.46g/cm3
Boiling Point 456.1ºC at 760 mmHg
Melting Point 115 °C
Molecular Formula C10H8ClNO3
Molecular Weight 225.62800
Flash Point 229.7ºC
Exact Mass 225.01900
PSA 65.46000
LogP 2.61840
Index of Refraction 1.628

 Safety Information

Hazard Codes Xi
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

7-amino-3-methoxy-4-chloroisocoumarin
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
7-Amino-4-chlor-3-methoxyisocumarin
3-methoxy-4-chloro-7-aminoisocoumarin
7-amino-4-chloro-3-methoxy-isochromen-1-one