1-(二氯乙酰基)-6-(2-呋喃甲酰氧基)-1,2,3,4-四氢喹啉

• 常用名: 1-(二氯乙酰基)-6-(2-呋喃甲酰氧基)-1,2,3,4-四氢喹啉
• 英文名: Quinfamide
• CAS号: 62265-68-3
• 分子量: 354.18
• 密度: 1.428g/cm3
• 沸点: 551.3ºC at 760mmHg
• 分子式: C₁₆H₁₃Cl₂NO₄
• 熔点: 145-146ºC
• 闪点: 287.2ºC

用途

Quinfamide 是一种抗阿米巴菌剂。Quinfamide可用于治疗阿米巴病、蠕虫病等热带寄生虫感染的疾病。

名称

• 中文名: 喹法米特
• 英文名: [1-(2,2-dichloroacetyl)-3,4-dihydro-2H-quinolin-6-yl] furan-2-carboxylate
• 中文别名: 呋醋喹酯 | 1-(二氯乙酰基)-6-(2-呋喃甲酰氧基)-1,2,3,4-四氢喹啉

生物活性

• 描述: Quinfamide 是一种抗阿米巴菌剂。Quinfamide可用于治疗阿米巴病、蠕虫病等热带寄生虫感染的疾病。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Davila-Gutierrez CE, et al. Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. Am J Trop Med Hyg. 2002 Mar;66(3):251-4.

物理化学性质

• 密度: 1.428g/cm3
• 沸点: 551.3ºC at 760mmHg
• 熔点: 145-146ºC
• 分子式: C₁₆H₁₃Cl₂NO₄
• 分子量: 354.18
• 闪点: 287.2ºC
• 精确质量: 353.02200
• PSA: 59.75000
• LogP: 3.64670
• InChIKey: SBJGFIXQRZOVTO-UHFFFAOYSA-N
• SMILES: O=C(Oc1ccc2c(c1)CCCN2C(=O)C(Cl)Cl)c1ccco1
• 折射率: 1.599
• 储存条件: 2-8°C

毒性和生态

安全信息

• 海关编码: 2934999090

海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

查看更多实验

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291800

实验名称：Binding affinity towards human ADRA2A in an in vitro assay with cellular components m... 来源：ChEMBL 靶标：Alpha-2A adrenergic receptor External Id：CHEMBL5291736

实验名称：Binding affinity towards human PGR in an in vitro assay with cellular components meas... 来源：ChEMBL 靶标：Progesterone receptor External Id：CHEMBL5291863

实验名称：Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluor... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291731

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291792

实验名称：Binding affinity towards human ADORA3 (agonistic activity) in an in vitro assay with ... 来源：ChEMBL 靶标：Adenosine receptor A3 External Id：CHEMBL5291728

实验名称：Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay m... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A External Id：CHEMBL5291856

实验名称：Antiamebic activity against Entamoeba criceti infected in hamster assessed as reducti... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3231323

实验名称：Binding affinity towards human OPRM1 in an in vitro assay with cellular components me... 来源：ChEMBL 靶标：Mu-type opioid receptor External Id：CHEMBL5291855

实验名称：Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured... 来源：ChEMBL 靶标：Alpha-1A adrenergic receptor External Id：CHEMBL5291730

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英文别名

• 1-(dichloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl 2-furoate
• Quinfamido [INN-Spanish]
• Quinfamide
• Quinfamidum [INN-Latin]
• 1-(dichloroacetyl)-6-(2-furoyloxy)-1,2,3,4-tetrahydroquinoline
• EINECS 263-478-1
• Amenide