62265-68-3

• 常用中文名：1-(二氯乙酰基)-6-(2-呋喃甲酰氧基)-1,2,3,4-四氢喹啉
• 常用英文名：Quinfamide
• CAS号：62265-68-3
• 分子式：C₁₆H₁₃Cl₂NO₄
• 分子量：354.18
• 相关类别： 信号通路 抗感染 寄生物
• 发布时间：2018-06-07 15:17:30
• 更新时间：2026-07-16 17:12:06
• Quinfamide 是一种抗阿米巴菌剂。Quinfamide可用于治疗阿米巴病、蠕虫病等热带寄生虫感染的疾病。

名称

• 中文名: 喹法米特
• 英文名: [1-(2,2-dichloroacetyl)-3,4-dihydro-2H-quinolin-6-yl] furan-2-carboxylate
• 中文别名: 喹法米特,10 MM DMSO 溶液; 喹酰胺; 喹法米特(喹法明); 呋醋喹酯; 1-(2,2-二氯乙酰基)-1,2,3,4-四氢喹啉-6-基 呋喃-2-羧酸酯
• 英文别名: Win-40014; 1-(Dichloroacetyl)-6-(2-furoyloxy)-1,2,3,4-tetrahydro-6-quinoline; 1-(dichloroacetyl)-6-(2-furoyloxy)-1,2,3,4-tetrahydroquinoline; 4-amino-N-(4-oxo-5,6,7,8-tetrahydro-1H-quinazolin-2-yl)benzenesulfonamide; Quinfamide (WIN-40014); Quinfamide, 10 mM in DMSO; 1-(2,2-Dichloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl furan-2-cboxylate; AMenide; AMenox; Quinfamido [INN-Spanish]; Amenide; EINECS 263-478-1; quinfamide; QUINTAMIDE; Quinfamidum [INN-Latin]; 2-Furancboxylic Acid 1-(2,2-Dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl Ester; 1-(dichloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl 2-furoate; 1-(Dichloroacetyl)-6-(2-furoyloxy)-1,2,3,4-tetrahydroquinoline; 2-Furancboxylic acid 1-(dichloroacetyl)-1,2,3,4-tetrahydroquinolin-6-yl ester; inhibit,Pasite,WIN40014,Quinfamide,Inhibitor,WIN

物化性质

• 密度: 1.428g/cm3
• 沸点: 551.3ºC at 760mmHg
• 熔点: 145-146ºC
• 分子式: C₁₆H₁₃Cl₂NO₄
• 分子量: 354.18
• 闪点: 287.2ºC
• 精确质量: 353.02200
• PSA: 59.75000
• LogP: 3.64670
• 折射率: 1.599
• 储存条件: 2-8°C

生物活性

• 描述: Quinfamide 是一种抗阿米巴菌剂。Quinfamide可用于治疗阿米巴病、蠕虫病等热带寄生虫感染的疾病。
• 相关类别:
  信号通路 >> 抗感染 >> 寄生物
  研究领域 >> 感染
• 参考文献:

  [1]. Davila-Gutierrez CE, et al. Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. Am J Trop Med Hyg. 2002 Mar;66(3):251-4.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LU0215000 CHEMICAL NAME : 2-Furancarboxylic acid, 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl ester CAS REGISTRY NUMBER : 62265-68-3 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C16-H13-Cl2-N-O4 MOLECULAR WEIGHT : 354.20 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,599,1979 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 22,599,1979

安全

• 海关编码: 2934999090

合成路线

527-69-5 62265-67-2 7440-44-0 ~% 62265-68-3

文献：US3997542 A1, ;

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%