Oxyntomodulin

• 常用名: Oxyntomodulin
• 英文名: Oxyntomodulin
• CAS号: 62340-29-8
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉₂H₂₉₅N₅₉O₆₀S
• 熔点: N/A
• 闪点: N/A

Oxyntomodulin用途

Oxyntomodulin 是一种含 37 个氨基酸的肽激素,是胰高血糖素样肽 1 (GLP-1) 受体激动剂。

Oxyntomodulin名称

• 中文名: 催产调节素(猪,牛)
• 英文名: (3S)-4-[[(1S)-2-[[(1S)-1-[[(1S)-4-amino-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-3-amino-1-[[(1S,2R)-1-[[(1S)-5-amino-1-[[(1S)-1-[[(1S)-3-amino-1-[[(1S)-5-amino-1-[[(1S)-3-amino-1-[[(1S)-3-amino-1-[[(1S,2S)-1-[[(1S)-1-carboxyethyl]carbamoyl]-2-methyl-butyl]carbamoyl]-3-oxo-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]carbamoyl]-3-oxo-propyl]carbamoyl]-4-guanidino-butyl]carbamoyl]pentyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]-3-methylsulfanyl-propyl]carbamoyl]-3-methyl-butyl]amino]-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]carbamoyl]-4-oxo-butyl]carbamoyl]-2-methyl-propyl]amino]-1-benzyl-2-oxo-ethyl]amino]-3-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-propanoyl]amino]-5-oxo-pentanoyl]amino]acetyl]amino]-3-hydroxy-butanoyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-3-carboxy-propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxy-propanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methyl-pentanoyl]amino]-3-carboxy-propanoyl]amino]-3-hydroxy-propanoyl]amino]-5-guanidino-pentanoyl]amino]-5-guanidino-pentanoyl]amino]propanoyl]amino]-5-oxo-pentanoyl]amino]-4-oxo-butanoic acid

Oxyntomodulin生物活性

• 描述: Oxyntomodulin 是一种含 37 个氨基酸的肽激素,是胰高血糖素样肽 1 (GLP-1) 受体激动剂。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胰高血糖素受体
• 体外研究: 催产素是一种在餐后状态下从肠道释放的肽类激素,可激活胰高血糖素样肽-1受体(GLP1R)和胰高血糖素受体(GCGR),从而使选择性GLP1R激动剂的体重降低。Oxyntomodulin主要通过前体激素转化酶1/3在肠道内分泌L细胞中产生。尽管与GLP-1和胰高血糖素相比,Oxyntomodulin在细胞系中是一种完全激动剂,但过度表达人类GLP1R和GCGR介导的cAMP积累[1]。
• 参考文献:

  [1]. Alessandro Pocai. Action and therapeutic potential of oxyntomodulin. Mol Metab. 2013 Dec 14;3(3):241-51.

Oxyntomodulin物理化学性质

• 分子式: C₁₉₂H₂₉₅N₅₉O₆₀S
• InChIKey: PXZWGQLGAKCNKD-DPNMSELWSA-N
• SMILES: CCC(C)C(NC(=O)C(CC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(CCSC)NC(=O)C(CC(C)C)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(CCC(N)=O)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CO)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(C)O)C(=O)NC(C)C(=O)O
• 储存条件: -20°C

Oxyntomodulin靶点实验

查看更多实验

实验名称：Metabolic stability in human plasma assessed as half life of DPP4-mediated compound d... 来源：ChEMBL 靶标：Dipeptidyl peptidase 4 External Id：CHEMBL3090294

实验名称：Agonist activity at GCG receptor (unknown origin) assessed as stimulation of cAMP pro... 来源：ChEMBL 靶标：Glucagon receptor External Id：CHEMBL3091139

实验名称：Agonist activity at human GLP-1R expressed in African green monkey COS7 cells assesse... 来源：ChEMBL 靶标：Glucagon-like peptide 1 receptor External Id：CHEMBL3090286

实验名称：Antidiabetic activity in sc dosed obese human assessed as body weight loss measured a... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL2404956

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