3-硝基-N-(喹啉-8-基)苯甲酰胺

• 常用名: 3-硝基-N-(喹啉-8-基)苯甲酰胺
• 英文名: VEGFR-2-IN-29
• CAS号: 62802-77-1
• 分子量: 293.27700
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₁N₃O₃
• 熔点: N/A
• 闪点: N/A

3-硝基-N-(喹啉-8-基)苯甲酰胺用途

VEGFR-2-IN-29(化合物5)是一种VEGFR-2抑制剂,其IC50为16.5nM[1]。

3-硝基-N-(喹啉-8-基)苯甲酰胺名称

• 中文名: 3-硝基-N-(喹啉-8-基)苯甲酰胺
• 英文名: 3-nitro-N-quinolin-8-ylbenzamide

3-硝基-N-(喹啉-8-基)苯甲酰胺生物活性

• 描述: VEGFR-2-IN-29(化合物5)是一种VEGFR-2抑制剂,其IC50为16.5nM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
• 靶点实验:

  VEGFR-2:16.5 nM (IC50)

• 体外研究: VEGFR-2-IN-29(化合物5)(72小时)抑制HUVEC增殖[1]。细胞增殖试验[1]细胞株：HUVEC浓度：孵育时间：72小时结果：显示15.8 nM和210 nM的IC50s对VEGF-和bFGF诱导的HUVEC-增殖有抑制作用。
• 参考文献:

  [1]. Yang Y, et al. Design, synthesis and biological evaluation of quinoline amide derivatives as novel VEGFR-2 inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6653-6.

3-硝基-N-(喹啉-8-基)苯甲酰胺物理化学性质

• 分子式: C₁₆H₁₁N₃O₃
• 分子量: 293.27700
• 精确质量: 293.08000
• PSA: 91.30000
• LogP: 4.30250
• InChIKey: IGPIXGIGDVQTEE-UHFFFAOYSA-N
• SMILES: O=C(Nc1cccc2cccnc12)c1cccc([N+](=O)[O-])c1
• 储存条件: 2-8°C， 干燥

3-硝基-N-(喹啉-8-基)苯甲酰胺靶点实验

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3-硝基-N-(喹啉-8-基)苯甲酰胺英文别名

• 3-Nitro-N-(8-chinolinyl)benzamid
• 3-Nitro-N-quinolin-8-yl-benzamide