环孢菌素 B

• 常用名: 环孢菌素 B
• 英文名: Cyclosporin B
• CAS号: 63775-95-1
• 分子量: 1188.585
• 密度: 1.0±0.1 g/cm3
• 沸点: 1289.7±65.0 °C at 760 mmHg
• 分子式: C₆₁H₁₀₉N₁₁O₁₂
• 熔点: 149-152ºC
• 闪点: 733.8±34.3 °C

环孢菌素 B用途

环孢菌素B是一类具有免疫抑制活性的非极性环寡肽。环孢素B用于预防器官移植中的移植物排斥反应[1]。

环孢菌素 B名称

• 中文名: 环孢菌素 B
• 英文名: Cyclosporin B
• 中文别名: 环孢菌素杂质B | 环[L-丙氨酰-D-丙氨酰-N-甲基-L-亮氨酰-N-甲基-L-亮氨酰-N-甲基-L-缬氨酰-3-羟基-N,4-二甲基-L-2-氨基-6-辛烯酰-L-丙氨酰-N-甲基甘氨酰-N-甲基-L-亮氨酰-L-缬氨酰-N-甲基-L-亮氨酰]

环孢菌素 B生物活性

• 描述: 环孢菌素B是一类具有免疫抑制活性的非极性环寡肽。环孢素B用于预防器官移植中的移植物排斥反应[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. von Wartburg A, Traber R. Cyclosporins, fungal metabolites with immunosuppressive activities. Prog Med Chem. 1988;25:1-33.

环孢菌素 B物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 1289.7±65.0 °C at 760 mmHg
• 熔点: 149-152ºC
• 分子式: C₆₁H₁₀₉N₁₁O₁₂
• 分子量: 1188.585
• 闪点: 733.8±34.3 °C
• 精确质量: 1187.825684
• PSA: 278.80000
• LogP: 2.82
• InChIKey: UCOQITKXMNKTKF-MXGZYYNMSA-N
• SMILES: CC=CCC(C)C(O)C1C(=O)NC(C)C(=O)N(C)CC(=O)N(C)C(CC(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(CC(C)C)C(=O)N(C)C(C(C)C)C(=O)N1C
• 外观性状: 无定形白色固体
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.468
• 储存条件: -20°C

环孢菌素 B安全信息

• 危害码 (欧洲): Xi

环孢菌素 B靶点实验

查看更多实验

实验名称：Apparent permeability in low-efflux MDCK2 cells at 2 uM by lucifer yellow dye-based U... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4328888

实验名称：1,9-decadiene/aqueous buffer solution partition coefficient, log D of the compound in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4328887

实验名称：Thermodynamic aqueous solubility of compound in pH 7.4 PBS by UPLC-MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4328886

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Permeability of compound by PAMP assay 来源：ChEMBL 靶标：N/A External Id：CHEMBL5224055

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环孢菌素 B英文别名

• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(1R,2R,4E)-1-Hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28,30-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• CyclosporinB
• Antibiotic S 7481F2
• Ala2-cyclosporine
• (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(1R,2R,4E)-1-Hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28,30-decamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• Cyclosporin Impurity 2