Valopicitabine

• 常用名: Valopicitabine
• 英文名: Valopicitabine
• CAS号: 640281-90-9
• 分子量: 356.37400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₂₄N₄O₆
• 熔点: N/A
• 闪点: N/A

Valopicitabine用途

Valopicitabine (NM2830) 是 2'-C-methylcytidine (有效的抗 HCV 剂) 的有效前药,Valopicitabine 作为抗病毒剂,可用于慢性 HCV 感染的研究。

Valopicitabine名称

• 英文名: [(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)-4-methyloxolan-3-yl] (2S)-2-amino-3-methylbutanoate

Valopicitabine生物活性

• 描述: Valopicitabine (NM2830) 是 2'-C-methylcytidine (有效的抗 HCV 剂) 的有效前药,Valopicitabine 作为抗病毒剂,可用于慢性 HCV 感染的研究。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 靶点实验:

  HCV[1]

• 体内研究: 瓦洛西他滨(NM 283)对黑猩猩的慢性丙型肝炎病毒基因型1具有有效的抗病毒活性[1]。在Sprague-Dawley大鼠中,经口给药(100 mg/kg)后,瓦洛西他滨表现出中等Cmax(3.62 ug/mL)和终末消除半衰期(T1/2 0.64 h)[2]。
• 参考文献:

  [1]. Pierra C, et al. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70.

  [2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006 Nov 2;49(22):6614-20.

Valopicitabine物理化学性质

• 分子式: C₁₅H₂₄N₄O₆
• 分子量: 356.37400
• 精确质量: 356.17000
• PSA: 162.92000
• InChIKey: TVRCRTJYMVTEFS-ICGCPXGVSA-N
• SMILES: CC(C)C(N)C(=O)OC1C(CO)OC(n2ccc(N)nc2=O)C1(C)O

Valopicitabine靶点实验

查看更多实验

实验名称：Stability in cryopreserved primary human hepatocytes assessed as increase in intracel... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL1052574

实验名称：Stability in rat hepatocytes assessed as intracellular nucleoside triphosphate AUC (0... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL1052575

实验名称：Metabolic stability in rat liver assessed as nucleoside triphosphate formation at 1.5... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1021282

实验名称：Stability in human HBI10A cells assessed as intracellular nucleoside triphosphate AUC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1052570

实验名称：Stability in cryopreserved primary human hepatocytes assessed as intracellular nucleo... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL1052571

实验名称：Metabolic stability in rat liver assessed as nucleoside triphosphate formation at 30 ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1021281

实验名称：Selectivity index, ratio of CC50 for human HBI10A cells to EC50 for HCV infected in h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1052568

实验名称：Stability in human HBI10A cells assessed as intracellular nucleoside triphosphate AUC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1052569

实验名称：Antiviral activity against HCV infected in human assessed as log reduction in viral l... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL1262513

实验名称：AUC (0 to 2 hrs) in human hepatocytes assessed as conversion to 2'-C-methylcytidine t... 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL1061722

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Valopicitabine英文别名

• Valopicitabine [INN]
• NMC-283
• NM-283
• val-mCyd
• Valopicitabine
• UNII-I2T0B5G94M