CGP 12177 hydrochloride

• 常用名: CGP 12177 hydrochloride
• 英文名: CGP 12177 hydrochloride
• CAS号: 64208-32-8
• 分子量: 315.80
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₂₂ClN₃O₃
• 熔点: N/A
• 闪点: N/A

CGP 12177 hydrochloride用途

CGP 12177 ((±)-CGP 12177) hydrochloride 是一种 β Adrenergic Receptor 配体。 CGP 12177 hydrochloride 是 β1- 和 β2-AR 的高亲和力拮抗剂。 CGP 12177 hydrochloride 还显示出以较低的亲和力与 β3-AR 相互作用,并对啮齿动物和人类 β3-AR 表现出部分激动剂活性。 CGP 12177 hydrochloride 对大鼠肺动脉中的 α1-AR 表现出部分激动剂特性。

CGP 12177 hydrochloride名称

• 英文名: 4-[3-(tert-butylamino)-2-hydroxypropoxy]-1,3-dihydrobenzimidazol-2-one,hydrochloride

CGP 12177 hydrochloride生物活性

• 描述: CGP 12177 ((±)-CGP 12177) hydrochloride 是一种 β Adrenergic Receptor 配体。 CGP 12177 hydrochloride 是 β1- 和 β2-AR 的高亲和力拮抗剂。 CGP 12177 hydrochloride 还显示出以较低的亲和力与 β3-AR 相互作用,并对啮齿动物和人类 β3-AR 表现出部分激动剂活性。 CGP 12177 hydrochloride 对大鼠肺动脉中的 α1-AR 表现出部分激动剂特性。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体
• 靶点实验:

  Beta-1 adrenergic receptor

  Beta-2 adrenergic receptor

  Beta-3 adrenergic receptor

  α1-adrenergic receptor

• 参考文献:

  [1]. Leblais V, et al. Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery. J Pharmacol Exp Ther. 2004 Apr;309(1):137-45.

CGP 12177 hydrochloride物理化学性质

• 分子式: C₁₄H₂₂ClN₃O₃
• 分子量: 315.80
• 精确质量: 315.13500
• PSA: 90.14000
• LogP: 2.17690
• InChIKey: YQVFCYCTITZLSX-UHFFFAOYSA-N
• SMILES: CC(C)(C)NCC(O)COc1cccc2[nH]c(=O)[nH]c12.Cl

CGP 12177 hydrochloride安全信息

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport

CGP 12177 hydrochloride靶点实验

查看更多实验

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实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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实验名称：MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint... 来源：Broad Institute 靶标：N/A External Id：2084-01_Activator_SinglePoint_HTS_Activity

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