Hepln-13

• 常用名: Hepln-13
• 英文名: HepIn-13
• CAS号: 64369-13-7
• 分子量: 325.20300
• 密度: 1.444g/cm3
• 沸点: 533.3ºC at 760 mmHg
• 分子式: C₁₇H₁₃BrN₂
• 熔点: N/A
• 闪点: 276.4ºC

Hepln-13用途

Hepln-13是一种有效的口服活性肝素抑制剂,IC50为0.33µM。Hepln-13可用于转移性前列腺癌的研究[1]。

Hepln-13名称

• 中文名: 2-(4-溴苯基)-2,3-二氢-1H-呸啶
• 英文名: 2-(4-Brom-phenyl)-2,3-dihydro-1H-perimidin

Hepln-13生物活性

• 描述: Hepln-13是一种有效的口服活性肝素抑制剂,IC50为0.33µM。Hepln-13可用于转移性前列腺癌的研究[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 靶点实验:

  IC50: 0.33 μM (Hepsin)

• 体外研究: Hepln-13(10µM；2小时；293细胞)抑制分裂[1]。westernblot分析[1]细胞系：293细胞浓度：10µM培养时间：2小时结果：抑制分裂。
• 体内研究: HepIn-13显示出与前列腺癌表型相关的Hepsin过表达的剂量依赖性抑制,并阻断前列腺癌转移[1]。
• 参考文献:

  [1]. Tang X, et al. Targeted inhibition of cell-surface serine protease Hepsin blocks prostate cancer bone metastasis. Oncotarget. 2014;5(5):1352-1362.

Hepln-13物理化学性质

• 密度: 1.444g/cm3
• 沸点: 533.3ºC at 760 mmHg
• 分子式: C₁₇H₁₃BrN₂
• 分子量: 325.20300
• 闪点: 276.4ºC
• 精确质量: 324.02600
• PSA: 24.06000
• LogP: 5.41450
• InChIKey: YSRRRCGJBGQBDM-UHFFFAOYSA-N
• SMILES: Brc1ccc(C2Nc3cccc4cccc(c34)N2)cc1
• 外观性状: 固体
• 折射率: 1.688
• 储存条件: 2-8°C，密封，干燥

Hepln-13靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：qHTS of TDP-43 Inhibitors: NCGC Sytravon Library Screen 来源：NCGC External Id：tdp43-p2-repeat

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Confirmatory qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 ... 来源：NCGC External Id：epac1-activator-f1f2f3f4

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Hepln-13英文别名

• 1h-naphth[1,2-e][1,3]oxazine,2-(4-bromophenyl)-2,3-dihydro
• 2-(4-bromo-phenyl)-2,3-dihydro-1H-perimidine
• 2-<4-Brom-phenyl>-2.3-dihydro-1H-naphth<1.2-e>-1.3-oxazin
• 2-(4-bromo-phenyl)-2,3-dihydro-1H-naphth[1,2-e][1,3]oxazine
• 2-(4-bromophenyl)-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine