(R)-SLV 319

• 常用名: (R)-SLV 319
• 英文名: (R)-SLV 319
• CAS号: 656827-86-0
• 分子量: 487.40
• 密度: 1.4±0.1 g/cm3
• 沸点: 623.2±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₀Cl₂N₄O₂S
• 熔点: N/A
• 闪点: 330.7±34.3 °C

(R)-SLV 319用途

(R) -SLV 319是一种有效的选择性大麻素受体1(CB1)拮抗剂,Ki值为894 nM。(R) -SLV 319是SLV 319的右旋对应物[1]

(R)-SLV 319名称

• 英文名: (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide

(R)-SLV 319生物活性

• 描述: (R) -SLV 319是一种有效的选择性大麻素受体1(CB1)拮抗剂,Ki值为894 nM。(R) -SLV 319是SLV 319的右旋对应物[1]
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
• 靶点实验:

  CB1:894 nM (Ki)

• 参考文献:

  [1]. Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem. 2004;47(3):627-643.

(R)-SLV 319物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 623.2±65.0 °C at 760 mmHg
• 分子式: C₂₃H₂₀Cl₂N₄O₂S
• 分子量: 487.40
• 闪点: 330.7±34.3 °C
• 精确质量: 486.068390
• PSA: 82.51000
• LogP: 4.67
• InChIKey: AXJQVVLKUYCICH-NRFANRHFSA-N
• SMILES: CN=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CC(c2ccccc2)C(c2ccc(Cl)cc2)=N1
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.663

(R)-SLV 319靶点实验

查看更多实验

实验名称：Antagonistic activity towards cannabinoid receptor 1 expressed as [3H]Arachidonic aci... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL658112

实验名称：In vivo effective dose to antagonise cannabinoid receptor 1 agonist (CP-55940) induce... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL884421

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Affinity to displace CP-55940 binding from Cannabinoid receptor 2 of human expressed ... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL659744

实验名称：Displacement of CP-55940 binding from recombinant human cannabinoid receptor 1 expres... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL657896

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：In vivo least effective dose required to antagonise cannabinoid receptor 1 agonist (W... 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL659664

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(R)-SLV 319英文别名

• 3-(4-chlorophenyl)-N-methyl-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboxamidine
• 3-(4-Chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-N'-methyl-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamide