Mycobactin-IN-1

• 常用名: Mycobactin-IN-1
• 英文名: Mycobactin-IN-1
• CAS号: 65840-95-1
• 分子量: 272.73
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₃ClN₂O
• 熔点: N/A
• 闪点: N/A

Mycobactin-IN-1用途

Mycobactin-IN-1(化合物44)是吡唑啉类似物,是一种抗分枝杆菌的Mycobactin生物合成抑制剂。Mycobactin-IN-1与水杨酸腺苷酸连接酶(MbtA)结合,后者是Mycobactin生物合成途径中的关键酶[1]。

Mycobactin-IN-1名称

• 英文名: Mycobactin-IN-1

Mycobactin-IN-1生物活性

• 描述: Mycobactin-IN-1(化合物44)是吡唑啉类似物,是一种抗分枝杆菌的Mycobactin生物合成抑制剂。Mycobactin-IN-1与水杨酸腺苷酸连接酶(MbtA)结合,后者是Mycobactin生物合成途径中的关键酶[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Mousumi Shyam，et al. Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.J Med Chem. 2022 Jan 13;65(1):234-256.

Mycobactin-IN-1物理化学性质

• 分子式: C₁₅H₁₃ClN₂O
• 分子量: 272.73
• InChIKey: BMOZIGVHPNPVGU-UHFFFAOYSA-N
• SMILES: Oc1ccccc1C1=NNC(c2ccc(Cl)cc2)C1

Mycobactin-IN-1靶点实验

查看更多实验

实验名称：Selectivity index, ratio of GIC90 for Cytotoxicity against human THP-1 cells to MIC90... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047865

实验名称：Selectivity index, ratio of GIC90 for Cytotoxicity against mouse RAW264.7 cells MIC90... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047864

实验名称：Selectivity index, ratio of GIC90 for cytotoxicity against human THP-1 cells to MIC90... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047863

实验名称：Selectivity index, ratio of GIC90 for cytotoxicity against mouse RAW264.7 cells to MI... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047862

实验名称：Selectivity index, ratio of GIC90 for Cytotoxicity against human THP-1 cells to MIC90... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047869

实验名称：Selectivity index, ratio of GIC90 for Cytotoxicity against mouse RAW264.7 cells to MI... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047868

实验名称：Selectivity index, ratio of GIC90 for Cytotoxicity against mouse human THP-1 cells to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047867

实验名称：Selectivity index, ratio of GIC90 for Cytotoxicity against mouse RAW264.7 cells to MI... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5047866

实验名称：Binding affinity to Mycobacterium tuberculosis MbtA assessed as change in thermal sta... 来源：ChEMBL 靶标：Salicyl-AMP ligase / salicyl-S-ArCP synthetase External Id：CHEMBL5047857

实验名称：Antibacterial activity against Mycobacterium smegmatis mc2155 ATCC 700084 cultured in... 来源：ChEMBL 靶标：Mycolicibacterium smegmatis External Id：CHEMBL5047856

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