阿昔洛韦单磷酸盐

• 常用名: 阿昔洛韦单磷酸盐
• 英文名: Acyclovir monophosphate
• CAS号: 66341-16-0
• 分子量: 305.185
• 密度: 2.1±0.1 g/cm3
• 沸点: 716.0±70.0 °C at 760 mmHg
• 分子式: C₈H₁₂N₅O₆P
• 熔点: >400ºC
• 闪点: 386.8±35.7 °C

阿昔洛韦单磷酸盐用途

单磷酸阿昔洛韦是一种有效的抗单纯疱疹病毒(HSV)药物。单磷酸阿昔洛韦通过抑制病毒DNA聚合酶阻断DNA合成,并终止病毒DNA的链延伸。单磷酸阿昔洛韦具有抗肿瘤活性[1][2]。

阿昔洛韦单磷酸盐名称

• 中文名: 阿昔洛韦单磷酸盐
• 英文名: Acyclovir Monophosphate

阿昔洛韦单磷酸盐生物活性

• 描述: 单磷酸阿昔洛韦是一种有效的抗单纯疱疹病毒(HSV)药物。单磷酸阿昔洛韦通过抑制病毒DNA聚合酶阻断DNA合成,并终止病毒DNA的链延伸。单磷酸阿昔洛韦具有抗肿瘤活性[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> HSV
  研究领域 >> 感染
• 参考文献:

  [1]. Yao J, et al. Turning an antiviral into an anticancer drug: nanoparticle delivery of acyclovir monophosphate. J Control Release. 2013 Sep 28;170(3):414-20.

  [2]. Elion GB, et al. Mechanism of action and selectivity of acyclovir. Am J Med. 1982 Jul 20;73(1A):7-13.

阿昔洛韦单磷酸盐物理化学性质

• 密度: 2.1±0.1 g/cm3
• 沸点: 716.0±70.0 °C at 760 mmHg
• 熔点: >400ºC
• 分子式: C₈H₁₂N₅O₆P
• 分子量: 305.185
• 闪点: 386.8±35.7 °C
• 精确质量: 305.052521
• PSA: 175.39000
• LogP: -2.21
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.780

阿昔洛韦单磷酸盐靶点实验

查看更多实验

实验名称：Selectivity ratio of CC50 for african green monkey Vero cells to EC50 for HSV1 L2 来源：ChEMBL 靶标：N/A External Id：CHEMBL2148469

实验名称：Activity of human wild type DNA polymerase gamma assessed as rate of excision of comp... 来源：ChEMBL 靶标：N/A External Id：CHEMBL940573

实验名称：Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells asse... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL2148470

实验名称：Selectivity ratio of CC50 for african green monkey Vero cells to EC50 for acyclovir-r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2148467

实验名称：Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue s... 来源：ChEMBL 靶标：Vero External Id：CHEMBL2148468

实验名称：Activity of wild type HSV1 DNA polymerase UL42 assessed as rate of excision of compou... 来源：ChEMBL 靶标：N/A External Id：CHEMBL940569

实验名称：Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition o... 来源：ChEMBL 靶标：Human alphaherpesvirus 1 External Id：CHEMBL2148471

实验名称：Activity of human wild-type DNA polymerase gamma assessed as rate of excision of comp... 来源：ChEMBL 靶标：N/A External Id：CHEMBL940581

实验名称：Activity of human wild type DNA polymerase gamma assessed as rate of excision of comp... 来源：ChEMBL 靶标：N/A External Id：CHEMBL940583

实验名称：Cytotoxicity against human Jurkat cells up to 2000 uM after 48 hrs by trypan blue sta... 来源：ChEMBL 靶标：Jurkat External Id：CHEMBL2148465

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阿昔洛韦单磷酸盐英文别名

• 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl dihydrogen phosphate
• Acyclovir monophosphate