![]() 3,3',5,5'-四碘甲腺-乙酸结构式
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常用名 | 3,3',5,5'-四碘甲腺-乙酸 | 英文名 | Tetrac |
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CAS号 | 67-30-1 | 分子量 | 747.82900 | |
密度 | 2.727g/cm3 | 沸点 | 544.8ºC at 760 mmHg | |
分子式 | C14H8I4O4 | 熔点 | 230 °C | |
MSDS | 中文版 美版 | 闪点 | 283.3ºC | |
符号 |
![]() GHS06 |
信号词 | Danger |
3,3',5,5'-四碘甲腺-乙酸用途本网站展示的所有产品仅用作科学研究,不可食用,不可用于人体或动物的临床诊断和治疗。
Tetrac (Tetraiodothyroacetic acid),L-甲状腺素 (T4) 的脱氨基类似物,是甲状腺素整合素受体拮抗剂。Tetrac 阻断 T3 和 T4 的作用以及不同的生长因子介导的血管生成。Tetra 还具有抗肿瘤活性。 |
中文名 | 3,3,5,5-四碘甲腺乙酸 |
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英文名 | 2-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]acetic acid |
英文别名 | 更多 |
描述 | Tetrac (Tetraiodothyroacetic acid),L-甲状腺素 (T4) 的脱氨基类似物,是甲状腺素整合素受体拮抗剂。Tetrac 阻断 T3 和 T4 的作用以及不同的生长因子介导的血管生成。Tetra 还具有抗肿瘤活性。 |
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相关类别 | |
体外研究 | 四环素(0.01-1μM;2-6d)诱导不同K-RAS状态的HT-29和HCT116细胞的抗增殖作用[3]。四环素(0.1μM;30min)抑制HT-29和HCT116细胞中ERK1/2的激活[3]。四环素(0.1μM;24h)抑制CCND1和c-Myc的表达,但促进CASP2和THBS1的表达[3]。细胞增殖试验[3]细胞系:HT-29和HCT116细胞浓度:0.01、0.1、1μM孵育时间:0、2、4、6d结果:诱导K-RAS野生型大肠癌细胞增殖。Western Blot分析[3]细胞株:HT-29和HCT116细胞浓度:0.1μM孵育时间:30min结果:抑制组成性激活的ERK1/2,这种抑制作用可通过抗整合素αvβ3抗体预处理而消除。 |
体内研究 | 四环素(35μg;p.o.40天)抑制小鼠肿瘤接种、生长和整合素表达[4]。动物模型:8周龄野生型雄性Balb/C小鼠接种102B16F10或B16LS9细胞[4]剂量:35μg/天给药:P.o.(加饮用水中)连续40天。结果:延缓了眼部黑色素瘤的发病。降低B16F10小鼠模型的S-100和整合素染色水平。 |
参考文献 |
密度 | 2.727g/cm3 |
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沸点 | 544.8ºC at 760 mmHg |
熔点 | 230 °C |
分子式 | C14H8I4O4 |
分子量 | 747.82900 |
闪点 | 283.3ºC |
精确质量 | 747.66000 |
PSA | 66.76000 |
LogP | 5.23000 |
外观性状 | 固体;White to Yellow to Green powder to crystal |
折射率 | 1.801 |
储存条件 | <0°C;避免加热 |
符号 |
![]() GHS06 |
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信号词 | Danger |
危害声明 | H300 |
警示性声明 | P264-P301 + P310 |
个人防护装备 | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
危害码 (欧洲) | T+ |
风险声明 (欧洲) | 28 |
安全声明 (欧洲) | 45 |
危险品运输编码 | UN 2811 6.1/PG 1 |
RTECS号 | CY1585800 |
危险类别 | 6.1 |
海关编码 | 2918990090 |
~90% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:Bridoux, Alexandre; Khan, Riaz A.; Chen, Celei; Cheve, Gwenael; Cui, Huadong; Dyskin, Evgeny; Yasri, Aziz; Mousa, Shaker A. Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 871 - 882 |
~% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:US2011/105482 A1, ; |
~% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:US2011/105482 A1, ; |
~% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:US2011/105482 A1, ; |
~% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:Biochemical Journal, , vol. 63, p. 601,603 |
~% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:US2011/105482 A1, ; |
~% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:Biochemical Journal, , vol. 50, p. 438 |
~% 3,3',5,5'-四碘甲腺-乙酸 67-30-1 |
文献:Biochemical Journal, , vol. 50, p. 438 |
3,3',5,5'-四碘甲腺-乙酸上游产品 8 | |
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3,3',5,5'-四碘甲腺-乙酸下游产品 0 |
海关编码 | 2918990090 |
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中文概述 | 2918990090. 其他含其他附加含氧基羧酸(包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Tetraiodothyroacetic acid-tagged liposomes for enhanced delivery of anticancer drug to tumor tissue via integrin receptor
J. Control. Release 164(2) , 213-20, (2012) Nanoparticles have demonstrated potential for promoting drug delivery to tumor sites and enhancing uptake. Here, we report tetraiodothyroacetic acid (tetrac) as a promising new targeting moiety for de... |
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Tetraiodothyroacetic acid and tetraiodothyroacetic acid nanoparticle effectively inhibit the growth of human follicular thyroid cell carcinoma.
Thyroid 20(3) , 281-6, (2010) Tetraiodothyroacetic acid (tetrac) is a deaminated analogue of L-thyroxine that blocks the actions of L-thyroxine and 3,5,3'-triiodo-L-thyronine at the cell surface receptor for thyroid hormone on int... |
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Tetraiodothyroacetic acid and its nanoformulation inhibit thyroid hormone stimulation of non-small cell lung cancer cells in vitro and its growth in xenografts.
Lung Cancer 76(1) , 39-45, (2012) Thyroid hormone stimulates cell proliferation of several types of cancers and stimulates cancer-relevant angiogenesis. In the present study, we investigated the proliferative effect of thyroid hormone... |
5-diiodophenoxy)-3 |
Thyroacetic acid,3,3',5,5'-tetraiodo |
3,5-Diiodo-4-(4-hydroxy-3,5-diiodophenoxy)benzeneacetic acid |
Tetrac |
MFCD00055932 |
[4-(4-hydroxy-3 |
4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenylacetic acid |
Benzeneacetic acid,3,5-diiodo-4-(4-hydroxy-3,5-diiodophenoxy) |
3,3',5,5'-TETRAIODOTHYROACETIC ACID |
Tetraiodothyroacetic acid |
Acide 3,5,3',5'-tetraiodothyroacetique [French] |
5-diiodophenyl] acetic acid |
EINECS 200-649-1 |