模绕酮酸

• 常用名: 模绕酮酸
• 英文名: moronic acid
• CAS号: 6713-27-5
• 分子量: 454.68
• 密度: 1.1±0.1 g/cm3
• 沸点: 550.0±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₆O₃
• 熔点: 212 °C(dec.)
• 闪点: 300.5±26.6 °C

模绕酮酸用途

摩洛哥酸是一种三萜类化合物,是一种抗艾滋病病毒的药物。摩洛哥酸抑制病毒复制,EC50值<1μg/mL,对H9淋巴细胞显示细胞毒性,IC50值为18.6μg/mL。摩洛哥酸可以从巴西蜂胶中分离得到[1]。

模绕酮酸名称

• 中文名: 黄莲木酸
• 英文名: moronic acid

模绕酮酸生物活性

• 描述: 摩洛哥酸是一种三萜类化合物,是一种抗艾滋病病毒的药物。摩洛哥酸抑制病毒复制,EC50值<1μg/mL,对H9淋巴细胞显示细胞毒性,IC50值为18.6μg/mL。摩洛哥酸可以从巴西蜂胶中分离得到[1]。
• 相关类别:
  信号通路 >> 抗感染 >> HIV
  研究领域 >> 感染
• 参考文献:

  [1]. Ito J, et al. Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Nat Prod. 2001 Oct;64(10):1278-81.

模绕酮酸物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 550.0±50.0 °C at 760 mmHg
• 熔点: 212 °C(dec.)
• 分子式: C₃₀H₄₆O₃
• 分子量: 454.68
• 闪点: 300.5±26.6 °C
• 精确质量: 454.344696
• PSA: 54.37000
• LogP: 8.53
• InChIKey: UMYJVVZWBKIXQQ-QALSDZMNSA-N
• SMILES: CC1(C)C=C2C3CCC4C5(C)CCC(=O)C(C)(C)C5CCC4(C)C3(C)CCC2(C(=O)O)CC1
• 外观性状: 固体
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.552
• 储存条件: 室温

模绕酮酸靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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模绕酮酸英文别名

• (4aS,6aR,6aR,6bR,8aR,12aR,14aS)-2,2,6a,6b,9,9,12a-heptamethyl-10-oxo-4,5,6,6a,7,8,8a,11,12,13,14,14a-dodecahydro-3H-picene-4a-carboxylic acid
• 3-Oxoolean-18-en-28-oic acid
• moronic acid
• Moronsaeure