(+/-)-双氮奋兴

• 常用名: (+/-)-双氮奋兴
• 英文名: Diclofensine
• CAS号: 67165-56-4
• 分子量: 322.229
• 密度: 1.2±0.1 g/cm3
• 沸点: 422.6±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇Cl₂NO
• 熔点: N/A
• 闪点: 209.4±28.7 °C

(+/-)-双氮奋兴用途

Diclofensine(Ro-8-4650)是高效单胺再摄取抑制剂,大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。

(+/-)-双氮奋兴名称

• 中文名: (+/-)-双氮奋兴
• 英文名: 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
• 中文别名: Diclofensine 盐酸盐 | Diclofensine 盐酸盐

(+/-)-双氮奋兴生物活性

• 描述: Diclofensine(Ro-8-4650)是高效单胺再摄取抑制剂,大鼠脑突触体中阻断多巴胺、去甲肾上腺素和5-羟色胺的IC50值分别为0.74、2.3和3.7nM。
• 相关类别:
  信号通路 >> 神经信号通路 >> 多巴胺转运蛋白
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44(5):1615-22.

  [2]. Gasic S, et al. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39(5):582-5.

  [3]. Di Renzo G, et al. Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine. Life Sci. 1988;42(21):2161-9.

(+/-)-双氮奋兴物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 422.6±45.0 °C at 760 mmHg
• 分子式: C₁₇H₁₇Cl₂NO
• 分子量: 322.229
• 闪点: 209.4±28.7 °C
• 精确质量: 321.068726
• PSA: 12.47000
• LogP: 4.42
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.591
• 储存条件: 2-8℃

(+/-)-双氮奋兴安全信息

• 海关编码: 2933499090

(+/-)-双氮奋兴海关

• 海关编码: 2933499090
• 中文概述: 2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

(+/-)-双氮奋兴靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Binding affinity towards Dopamine receptor D1 at 1.0 uM concentration 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL670387

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

实验名称：Primary qHTS for Identification of Small Molecule Inhibitors of Huntingtin Promoter A... 来源：NCGC External Id：huntington-HTT2-p1-FF-overN

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(+/-)-双氮奋兴英文别名

• (±)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline
• (±)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
• 4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-3,4-dihydro-1H-isoquinoline
• Ro 8-4650
• Diclofensine
• 4-(3,4-Dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline