RSV604

• 常用名: RSV604
• 英文名: RSV-604
• CAS号: 676128-63-5
• 分子量: 388.39400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₇FN₄O₂
• 熔点: N/A
• 闪点: N/A

RSV604用途

RSV604是RSV病毒复制抑制剂,EC50值0.86uM,RSV核蛋白抑制剂。

RSV604名称

• 中文名: RSV604
• 英文名: (S)-1-(2-fluoro-phenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea

RSV604生物活性

• 描述: RSV604是RSV病毒复制抑制剂,EC50值0.86uM,RSV核蛋白抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> RSV
  研究领域 >> 感染
• 参考文献:

  [1]. Henderson EA, et al. 1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate. J Med Chem. 2007 Apr 5;50(7):1685-92.

  [2]. Chapman J, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication. Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53.

  [3]. Challa S, et al. Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7.

RSV604物理化学性质

• 分子式: C₂₂H₁₇FN₄O₂
• 分子量: 388.39400
• 精确质量: 388.13400
• PSA: 82.59000
• LogP: 3.80050
• InChIKey: MTPVBMVUENFFLL-HXUWFJFHSA-N
• SMILES: O=C(Nc1ccccc1F)NC1N=C(c2ccccc2)c2ccccc2NC1=O
• 储存条件: 2-8℃

RSV604靶点实验

查看更多实验

实验名称：NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C... 来源：NCGC 靶标：N/A External Id：adst_HEK293_Anti-infectives-02

实验名称：NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay 来源：NCGC 靶标：N/A External Id：adst_Celegans_Anti-infectives-o1

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Therapeutic index, CC50 for human Hep2 cells to EC50 for RSV RSS 来源：ChEMBL 靶标：N/A External Id：CHEMBL993163

实验名称：Antiviral activity against RSV RSS in Hep2 cells by XTT assay 来源：ChEMBL 靶标：Respiratory syncytial virus External Id：CHEMBL917119

实验名称：Antiviral activity against RSV infected human Hep2 cells assessed as reduction of pla... 来源：ChEMBL 靶标：Respiratory syncytial virus External Id：CHEMBL993172

实验名称：Antiviral activity against RSV RSS in Hep2 cells by ELISA 来源：ChEMBL 靶标：Respiratory syncytial virus External Id：CHEMBL918026

实验名称：Antiviral activity against RSV RSS in Hep2 cells by plaque assay 来源：ChEMBL 靶标：Respiratory syncytial virus External Id：CHEMBL918027

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

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RSV604英文别名

• rsv604
• rsv-604