白头翁皂苷 D

• 常用名: 白头翁皂苷 D
• 英文名: Pulsatilla saponin D
• CAS号: 68027-15-6
• 分子量: 913.096
• 密度: 1.4±0.1 g/cm3
• 沸点: 997.6±65.0 °C at 760 mmHg
• 分子式: C₄₇H₇₆O₁₇
• 熔点: N/A
• 闪点: 285.4±27.8 °C

白头翁皂苷 D用途

用于含量测定、鉴定、药理实验等。

白头翁皂苷 D名称

• 中文名: 白头翁皂甙D
• 英文名: hederagenin 3-O-α-L-rhamnopyranosyl(1-2)-(β-D-glucopyranosyl(1-4))-α-L-arabinopyranoside
• 中文别名: 白头翁皂苷D

白头翁皂苷 D生物活性

• 描述: Pulsatilla saponin D(SB365)可从Pulsatilla koreana的根中提取,可作为化疗保护剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 萜类化合物和糖苷
• 参考文献:

  [1]. Hong SW, et al. SB365, Pulsatilla saponin D, targets c-Met and exerts antiangiogenic and antitumor activities. Carcinogenesis. 2013 Sep;34(9):2156-69.

  [2]. Son MK, et al. SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells. Oncol Rep. 2013 Aug;30(2):801-8.

  [3]. Son MK, et al. SB365, Pulsatilla saponin D suppresses the proliferation of human colon cancer cells and induces apoptosis by modulating the AKT/mTOR signalling pathway. Food Chem. 2013 Jan 1;136(1):26-33.

白头翁皂苷 D物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 997.6±65.0 °C at 760 mmHg
• 分子式: C₄₇H₇₆O₁₇
• 分子量: 913.096
• 闪点: 285.4±27.8 °C
• 精确质量: 912.508240
• PSA: 274.75000
• LogP: 5.77
• InChIKey: SOLICHUQXFAOEP-YDIXZRNLSA-N
• SMILES: CC1OC(OC2C(OC3CCC4(C)C(CCC5(C)C4CC=C4C6CC(C)(C)CCC6(C(=O)O)CCC45C)C3(C)CO)OCC(OC3OC(CO)C(O)C(O)C3O)C2O)C(O)C(O)C1O
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.619
• 储存条件: -20°C

白头翁皂苷 D靶点实验

查看更多实验

实验名称：Cell membrane permeabilization in human A549 cells assessed as drug level causing dec... 来源：ChEMBL 靶标：A549 External Id：CHEMBL1031510

实验名称：Cell membrane permeabilization in human DLD1 cells assessed as drug level causing dec... 来源：ChEMBL 靶标：DLD-1 External Id：CHEMBL1031511

实验名称：Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test 来源：ChEMBL 靶标：DLD-1 External Id：CHEMBL1031508

实验名称：Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction test 来源：ChEMBL 靶标：N/A External Id：CHEMBL1031509

实验名称：Toxicity in sheep erythrocytes assessed as induction of hemolysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL1031506

实验名称：Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 24 ... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3429086

实验名称：Induction of cell cycle arrest in human L02 cells assessed as S phase accumulation at... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4822676

实验名称：Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test 来源：ChEMBL 靶标：A549 External Id：CHEMBL1031507

实验名称：Cytotoxicity against human Bel7402 cells assessed as inhibition of cell growth after ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3429087

实验名称：Induction of cell cycle arrest in human L02 cells assessed as G2/M phase accumulation... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4822677

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白头翁皂苷 D英文别名

• (3β)-3-{[6-Deoxy-α-L-mannopyranosyl-(1->2)-[β-D-glucopyranosyl-(1->4)]-α-L-arabinopyranosyl]oxy}-23-hydroxyolean-12-en-28-oic acid
• Hederagenin 3-O-Alpha-L-rhamnopYHanosyl(1→2)-(Beta-D-glucopYHanosyl(1→4))-Alpha-L-arabinopYHanoside
• Pulsatilla saponin D
• Hederagenin 3-O-Alpha-L-rhamnopyranosyl(1→2)-(Beta-D-glucopyranosyl(1→4))-Alpha-L-arabinopyranoside
• hederagenin 3-O--L-rhamnopyranosyl(1-2)-(-D-glucopyranosyl(1-4))--L-arabinopyranoside
• HEDERAGENIN 3-O-Α-L-RHAMNOPYRANOSYL(1→2)-(Β-D-GLUCOPYRANOSYL(1→4))-Α-L-ARABINOPYRANOSIDE