迪拉马尼

• 常用名: 迪拉马尼
• 英文名: Delamanid
• CAS号: 681492-22-8
• 分子量: 534.484
• 密度: 1.5±0.1 g/cm3
• 沸点: 653.7±65.0 °C at 760 mmHg
• 分子式: C₂₅H₂₅F₃N₄O₆
• 熔点: N/A
• 闪点: 349.1±34.3 °C

迪拉马尼用途

Delamanid是一个治疗耐多药结核病的药物，也是新的分枝杆菌细胞壁合成抑制剂。

迪拉马尼名称

• 中文名: 迪拉马尼
• 英文名: (2R)-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-3H-imidazo[2,1-b][1,3]oxazole

迪拉马尼生物活性

• 描述: Delamanid是一个治疗耐多药结核病的药物,也是新的分枝杆菌细胞壁合成抑制剂。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 癌症
• 参考文献:

  [1]. Sotgiu G et al. Delamanid (OPC-67683) for treatment of multi-drug-resistant tuberculosis. Expert Rev Anti Infect Ther. 2015 Mar;13(3):305-15.

  [2]. Xavier AS et al. Delamanid: A new armor in combating drug-resistant tuberculosis. J Pharmacol Pharmacother. 2014 Jul;5(3):222-4

  [3]. Mallikaarjun S et al. Delamanid Coadministered with Antiretroviral Drugs or Antituberculosis Drugs Shows No Clinically Relevant Drug-Drug Interactions in Healthy Subjects. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5976-85.

  [4]. Patterson S et al.The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis. Elife. 2016 May 24;5.

迪拉马尼物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 653.7±65.0 °C at 760 mmHg
• 分子式: C₂₅H₂₅F₃N₄O₆
• 分子量: 534.484
• 闪点: 349.1±34.3 °C
• 精确质量: 534.172607
• PSA: 103.80000
• LogP: 4.75
• InChIKey: XDAOLTSRNUSPPH-XMMPIXPASA-N
• SMILES: CC1(COc2ccc(N3CCC(Oc4ccc(OC(F)(F)F)cc4)CC3)cc2)Cn2cc([N+](=O)[O-])nc2O1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.611
• 储存条件: -20℃

迪拉马尼靶点实验

查看更多实验

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as bacte... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5117242

实验名称：Decrease in Mycobacterium tuberculosis count in mouse pulmonary 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL909877

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as bacte... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5117243

实验名称：Cytotoxicity against African green monkey vero cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：Vero External Id：CHEMBL5117244

实验名称：Antituberculosis activity against rifampicin resistant Mycobacterium tuberculosis H37... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL909872

实验名称：Reduction in log CFU of Mycobacterium tuberculosis Kurono infected in mouse lung at 5... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL909873

实验名称：Metabolic stability in human liver microsomes assessed as half life 来源：ChEMBL 靶标：N/A External Id：CHEMBL5117239

实验名称：Reduction in log CFU of Mycobacterium tuberculosis Kurono infected in mouse lung at 0... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL909874

实验名称：Metabolic stability in rat liver microsomes assessed as half life 来源：ChEMBL 靶标：N/A External Id：CHEMBL5117240

实验名称：Reduction in log CFU of Mycobacterium tuberculosis Kurono infected in mouse lung at 1... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL909875

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迪拉马尼英文别名

• Delamanid
• (2R)-2-methyl-6-nitro-2-[(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)methyl]-2,3-dihydroimidazo[2,1-b][1,3]oxazole
• (2R)-2-Methyl-6-nitro-2-[(4-{4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl}phenoxy)methyl]-2,3-dihydroimidazo[2,1-b][1,3]oxazole
• UNII-8OOT6M1PC7
• OPC-67683